Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
| ▸ | SMG1 | Q96Q15 | 3/20 | 0.44 |
| ▸ | CDK2 | P24941 | 2/20 | 0.44 |
| ▸ | CDK1 | P06493 | 1/20 | 0.44 |
| ▸ | JAK1 | P23458 | 1/20 | 0.44 |
| ▸ | JAK3 | P52333 | 1/20 | 0.44 |
| ▸ | ZAP70 | P43403 | 1/20 | 0.43 |
| ▸ | PLK4 | O00444 | 5/20 | 0.42 |
| ▸ | MTOR | P42345 | 1/20 | 0.42 |
| ▸ | JAK2 | O60674 | 4/20 | 0.41 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.41 |
| ▸ | KDR | P35968 | 1/20 | 0.41 |
| ▸ | EPHB4 | P54760 | 1/20 | 0.41 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.41 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.41 |
| ▸ | CCNK | O75909 | 1/20 | 0.40 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.40 |
| ▸ | CCND3 | P30281 | 1/20 | 0.40 |
| ▸ | CDK9 | P50750 | 1/20 | 0.40 |
| ▸ | CDK6 | Q00534 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5760255 | 0.84 | SMG1 (0.44) | CYP1A2SMG1CDK2CDK1JAK1 | |
| SCHEMBL5759805 | 0.83 | CDK2 (0.41) | CDK2CDK1MTORFGFR1KDR | |
| SCHEMBL5760461 | 0.81 | ROCK1 (0.40) | CDK2JAK3PLK4JAK2KDR | |
| SCHEMBL5758741 | 0.80 | L3MBTL1 (0.52) | CDK2KDRSRC | |
| SCHEMBL5761986 | 0.79 | CDK4 (0.42) | CDK2JAK3JAK2KDR | |
| SCHEMBL5759742 | 0.79 | SCN9A (0.42) | SMG1CDK2CDK1JAK3JAK2 | |
| SCHEMBL5759581 | 0.79 | ROCK1 (0.55) | ZAP70 | |
| SCHEMBL5758924 | 0.78 | IDH1 (0.52) | PLK4KDR | |
| SCHEMBL5757754 | 0.77 | PTK2 (0.47) | CDK2JAK1JAK3JAK2FGFR1 | |
| SCHEMBL5760158 | 0.77 | IGF1R (0.43) | KDRPDGFRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1242403-B1 | 2,4-DIAMINOPYRIMIDINE COMPOUNDS USFUL AS IMMUNOSUPPRESSANTS | PFIZER PROD INC (US) | 2006-01-04 | — | — | EP | claimed |