Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 2/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 2/20 | 0.36 |
| ▸ | SRC | P12931 | 2/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | ABL1 | P00519 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | GLA | P06280 | 1/20 | 0.36 |
| ▸ | HTR1A | P08908 | 1/20 | 0.35 |
| ▸ | DRD2 | P14416 | 1/20 | 0.35 |
| ▸ | HTR2A | P28223 | 1/20 | 0.35 |
| ▸ | HTR7 | P34969 | 1/20 | 0.35 |
| ▸ | HTR6 | P50406 | 1/20 | 0.35 |
| ▸ | PDE1C | Q14123 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5764508 | 0.90 | PPARG (0.40) | MAPTPLA2G2ATSHRALDH1A1HSD17B10 | |
| SCHEMBL5765021 | 0.90 | GAA (0.38) | MAPTPLA2G2AHTTALDH1A1HSD17B10 | |
| SCHEMBL5762337 | 0.84 | MAPT (0.41) | MAPTL3MBTL1PLA2G2AALDH1A1POLB | |
| SCHEMBL5763363 | 0.81 | ALOX5AP (0.42) | MAPTHTTRXFP1ALDH1A1POLB | |
| SCHEMBL5764971 | 0.80 | PLA2G1B (0.40) | MAPTPLA2G2AALDH1A1POLB | |
| SCHEMBL5765690 | 0.80 | PLA2G2A (0.48) | PLA2G2A | |
| SCHEMBL5764324 | 0.78 | ALDH1A1 (0.47) | MAPTHTTTSHRRXFP1ALDH1A1 | |
| SCHEMBL5766775 | 0.78 | PLA2G2A (0.40) | MAPTPLA2G2ATSHRALDH1A1TP53 | |
| SCHEMBL5765093 | 0.73 | PTGDR2 (0.42) | MAPTPLA2G2AHTTALDH1A1HSD17B10 | |
| SCHEMBL5765082 | 0.73 | PKM (0.43) | MAPTPLA2G2ATSHRALDH1A1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1091738-B1 | BICYCLIC sPLA 2 INHIBITORS | LILLY CO ELI (US) | 2006-12-06 | — | — | EP | disclosed |
| US-6384041-B1 | ANTIINFLAMMATORY AGENT, TREATMENT OF SHOCK AND ENZYME INHIBITORS | ELI LILLY AND COMPANY | 2002-05-07 | — | — | US | disclosed |