Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 4/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | PPARG | P37231 | 3/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.37 |
| ▸ | ABHD6 | Q9BV23 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 3/20 | 0.36 |
| ▸ | THRB | P10828 | 1/20 | 0.36 |
| ▸ | PTGER3 | P43115 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 3/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | SCD | O00767 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5764178 | 0.89 | MAPT (0.40) | LMNAHTTTP53MAPTTSHR | |
| SCHEMBL5764508 | 0.88 | PPARG (0.40) | PPARGMAPTTSHRPOLB | |
| SCHEMBL5764801 | 0.85 | AURKA (0.42) | LMNAHTTPPARGSMN1; SMN2ABHD6 | |
| SCHEMBL5763363 | 0.84 | ALOX5AP (0.42) | HTTMAPTPOLB | |
| SCHEMBL5763931 | 0.82 | HSP90AA1 (0.40) | PPARGSMN1; SMN2TP53PTGER3POLB | |
| SCHEMBL5763509 | 0.80 | PLA2G2A (0.44) | — | |
| SCHEMBL5764441 | 0.79 | ALDH1A1 (0.39) | LMNAHTTSMN1; SMN2ABHD6TP53 | |
| SCHEMBL5764971 | 0.78 | PLA2G1B (0.40) | PPARGMAPTPOLB | |
| SCHEMBL5762337 | 0.73 | MAPT (0.41) | LMNASMN1; SMN2TP53MAPTMAPK1 | |
| SCHEMBL5762150 | 0.72 | PLA2G2A (0.49) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1091738-B1 | BICYCLIC sPLA 2 INHIBITORS | LILLY CO ELI (US) | 2006-12-06 | — | — | EP | disclosed |
| US-6384041-B1 | ANTIINFLAMMATORY AGENT, TREATMENT OF SHOCK AND ENZYME INHIBITORS | ELI LILLY AND COMPANY | 2002-05-07 | — | — | US | disclosed |