Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | MAPK14 | Q16539 | 3/20 | 0.43 |
| ▸ | BCHE | P06276 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.40 |
| ▸ | CNR2 | P34972 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.37 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.37 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.37 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.37 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.37 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.37 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.37 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.37 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.37 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Trifluoroacetic Acid SCHEMBL5771101 | 0.92 | TP53 (0.46) | LMNABCHEMAPTMEN1KMT2A | |
| SCHEMBL5773332 | 0.86 | CNR2 (0.51) | LMNAMAPK14MAPTMEN1KMT2A | |
| Trifluoroacetic Acid SCHEMBL5771828 | 0.86 | GSK3B (0.42) | LMNAMAPK14MAPTKMT2ASMN1; SMN2 | |
| SCHEMBL5777386 | 0.86 | LMNA (0.47) | LMNAMAPK14MAPTMEN1KMT2A | |
| Trifluoroacetic Acid SCHEMBL5773568 | 0.85 | EPHX2 (0.52) | MAPK14MEN1KMT2ATAAR1TP53 | |
| Trifluoroacetic Acid SCHEMBL5772665 | 0.82 | NPC1 (0.52) | LMNAMAPTTP53SMN1; SMN2HDAC4 | |
| Trifluoroacetic Acid SCHEMBL5775470 | 0.82 | CNR2 (0.52) | MAPTMEN1KMT2ACNR2HDAC3 | |
| Trifluoroacetic Acid SCHEMBL5770756 | 0.82 | HDAC6 (0.42) | MAPTMEN1KMT2ACNR2HDAC3 | |
| SCHEMBL5773606 | 0.81 | MAPT (0.48) | LMNAMAPTMEN1KMT2ACNR2 | |
| SCHEMBL5771183 | 0.80 | ROCK2 (0.45) | LMNAMAPK14MAPTMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20060084690-A1 | Isoxazole derivatives | MOMOSE YU | 2006-04-20 | — | — | US | disclosed |
| US-7022725-B2 | Isoxazole derivatives | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2006-04-04 | — | — | US | disclosed |
| US-20040048908-A1 | Isoxazole derivatives | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2004-03-11 | — | — | US | disclosed |
| EP-1340749-A1 | ISOXAZOLE DERIVATIVES | Takeda Chemical Industries, Ltd. (JP) | 2003-09-03 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060084690-A1 | Isoxazole derivatives | INSR, GPR119, INSRR | LMNA 2770/4885MAPK14 1376/4885BCHE 1810/4885 |
| US-20040048908-A1 | Isoxazole derivatives | GPR119, INSR, IRS1 | LMNA 2605/4885MAPK14 1203/4885BCHE 2120/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.