Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.38 |
| ▸ | GAA | P10253 | 3/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | NAMPT | P43490 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Trifluoroacetic Acid SCHEMBL5772978 | 0.92 | GSK3B (0.52) | GSK3BSMN1; SMN2CYP3A4GAAALDH1A1 | |
| Trifluoroacetic Acid SCHEMBL5773568 | 0.91 | EPHX2 (0.52) | EPHX2MAPK14GAACYP1A2CYP2C9 | |
| Trifluoroacetic Acid SCHEMBL5773317 | 0.90 | CYP3A4 (0.53) | HTTLMNASMN1; SMN2CYP3A4GAA | |
| SCHEMBL5775471 | 0.87 | HDAC3 (0.46) | GSK3BHTTLMNASMN1; SMN2HPGD | |
| SCHEMBL5774072 | 0.87 | LMNA (0.54) | HTTLMNASMN1; SMN2CYP3A4GAA | |
| Trifluoroacetic Acid SCHEMBL5771064 | 0.86 | LMNA (0.44) | LMNAL3MBTL1MAPK14SMN1; SMN2MAPT | |
| Trifluoroacetic Acid SCHEMBL5770600 | 0.84 | HPGD (0.50) | LMNASMN1; SMN2GAAALDH1A1MAPT | |
| Trifluoroacetic Acid SCHEMBL5775717 | 0.83 | GSK3B (0.44) | GSK3BEPHX2SMN1; SMN2CYP1A2CYP2C9 | |
| Trifluoroacetic Acid SCHEMBL5771354 | 0.83 | ALDH1A1 (0.49) | HTTEPHX2LMNAL3MBTL1SMN1; SMN2 | |
| Trifluoroacetic Acid SCHEMBL5774473 | 0.83 | CYP3A4 (0.52) | GSK3BHTTLMNASMN1; SMN2CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20060084690-A1 | Isoxazole derivatives | MOMOSE YU | 2006-04-20 | — | — | US | disclosed |
| US-7022725-B2 | Isoxazole derivatives | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2006-04-04 | — | — | US | disclosed |
| US-20040048908-A1 | Isoxazole derivatives | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2004-03-11 | — | — | US | disclosed |
| EP-1340749-A1 | ISOXAZOLE DERIVATIVES | Takeda Chemical Industries, Ltd. (JP) | 2003-09-03 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060084690-A1 | Isoxazole derivatives | INSR, GPR119, INSRR | GSK3B 1517/4885HTT 4375/4885EPHX2 1846/4885 |
| US-20040048908-A1 | Isoxazole derivatives | GPR119, INSR, IRS1 | GSK3B 2013/4885HTT 3773/4885EPHX2 2389/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.