Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.52 |
| ▸ | RAB9A | P51151 | 1/20 | 0.52 |
| ▸ | KLF5 | Q13887 | 1/20 | 0.52 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 4/20 | 0.46 |
| ▸ | EPHX2 | P34913 | 3/20 | 0.44 |
| ▸ | PKM | P14618 | 3/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | USP2 | O75604 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.43 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Trifluoroacetic Acid SCHEMBL5771101 | 0.90 | TP53 (0.46) | NPC1RAB9AKLF5LMNAALDH1A1 | |
| SCHEMBL5773606 | 0.88 | MAPT (0.48) | NPC1RAB9AKLF5LMNAALDH1A1 | |
| Trifluoroacetic Acid SCHEMBL5774473 | 0.85 | CYP3A4 (0.52) | LMNAALDH1A1SMN1; SMN2HTTMAPT | |
| Trifluoroacetic Acid SCHEMBL5773866 | 0.84 | ALDH1A1 (0.48) | LMNAALDH1A1SMN1; SMN2HTTTP53 | |
| Trifluoroacetic Acid SCHEMBL5776422 | 0.83 | MCHR1 (0.46) | NPC1ALDH1A1POLBSMN1; SMN2HDAC4 | |
| SCHEMBL5774865 | 0.83 | LMNA (0.61) | NPC1RAB9AKLF5NOTUMLMNA | |
| SCHEMBL5774003 | 0.83 | MGLL (0.50) | LMNAALDH1A1SMN1; SMN2HDAC4HDAC6 | |
| Trifluoroacetic Acid SCHEMBL5771064 | 0.82 | LMNA (0.44) | NPC1RAB9AKLF5LMNASMN1; SMN2 | |
| Trifluoroacetic Acid SCHEMBL5775554 | 0.82 | HDAC4 (0.43) | EPHX2ALDH1A1SMN1; SMN2HDAC4HDAC6 | |
| SCHEMBL5775672 | 0.82 | MAPT (0.50) | NPC1RAB9ALMNAALDH1A1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20060084690-A1 | Isoxazole derivatives | MOMOSE YU | 2006-04-20 | — | — | US | disclosed |
| US-7022725-B2 | Isoxazole derivatives | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2006-04-04 | — | — | US | disclosed |
| US-20040048908-A1 | Isoxazole derivatives | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2004-03-11 | — | — | US | disclosed |
| EP-1340749-A1 | ISOXAZOLE DERIVATIVES | Takeda Chemical Industries, Ltd. (JP) | 2003-09-03 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060084690-A1 | Isoxazole derivatives | INSR, GPR119, INSRR | NPC1 2417/4885RAB9A 3076/4885KLF5 3753/4885 |
| US-20040048908-A1 | Isoxazole derivatives | GPR119, INSR, IRS1 | NPC1 1770/4885RAB9A 3507/4885KLF5 3498/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.