Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 5/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.51 |
| ▸ | NPC1 | O15118 | 3/20 | 0.51 |
| ▸ | ATM | Q13315 | 1/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.47 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.47 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.46 |
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 2/20 | 0.44 |
| ▸ | TSHR | P16473 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 2/20 | 0.42 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5772042 | 0.89 | HDAC1 (0.48) | RAB9ASMN1; SMN2NPC1L3MBTL1HDAC1 | |
| SCHEMBL5777386 | 0.86 | LMNA (0.47) | SMN1; SMN2HCAR2ALDH1A1MAPTGAA | |
| SCHEMBL5771473 | 0.85 | L3MBTL1 (0.49) | SMN1; SMN2ATML3MBTL1HDAC1HDAC2 | |
| SCHEMBL5774014 | 0.81 | KDM4E (0.44) | SMN1; SMN2ATML3MBTL1HDAC1HDAC2 | |
| SCHEMBL5774012 | 0.81 | HCAR2 (0.38) | ATML3MBTL1HDAC1HDAC2HCAR2 | |
| SCHEMBL5771183 | 0.81 | ROCK2 (0.45) | SMN1; SMN2HDAC1HDAC2HCAR2ALDH1A1 | |
| SCHEMBL5772947 | 0.81 | MGLL (0.47) | HDAC1HDAC2HCAR2MAPTGAA | |
| SCHEMBL5774072 | 0.80 | LMNA (0.54) | RAB9ASMN1; SMN2ALDH1A1MAPTGAA | |
| SCHEMBL5769962 | 0.79 | SMN1; SMN2 (0.41) | RAB9ASMN1; SMN2NPC1HDAC1HDAC2 | |
| SCHEMBL5773900 | 0.79 | CYP1A2 (0.52) | RAB9ASMN1; SMN2NPC1L3MBTL1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20060084690-A1 | Isoxazole derivatives | MOMOSE YU | 2006-04-20 | — | — | US | disclosed |
| US-7022725-B2 | Isoxazole derivatives | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2006-04-04 | — | — | US | disclosed |
| US-20040048908-A1 | Isoxazole derivatives | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2004-03-11 | — | — | US | disclosed |
| EP-1340749-A1 | ISOXAZOLE DERIVATIVES | Takeda Chemical Industries, Ltd. (JP) | 2003-09-03 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060084690-A1 | Isoxazole derivatives | INSR, GPR119, INSRR | RAB9A 3076/4885SMN1; SMN2 3383/4885NPC1 2417/4885 |
| US-20040048908-A1 | Isoxazole derivatives | GPR119, INSR, IRS1 | RAB9A 3507/4885SMN1; SMN2 2449/4885NPC1 1770/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.