Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 2/20 | 0.52 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.52 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.52 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.52 |
| ▸ | MAPT | P10636 | 2/20 | 0.52 |
| ▸ | LMNA | P02545 | 3/20 | 0.47 |
| ▸ | HTT | P42858 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | SORT1 | Q99523 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | NAMPT | P43490 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.43 |
| ▸ | VNN1 | O95497 | 1/20 | 0.43 |
| ▸ | GSK3B | P49841 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Trifluoroacetic Acid SCHEMBL5773866 | 0.92 | ALDH1A1 (0.48) | CYP3A4CYP1A2CYP2C9CYP2C19SMN1; SMN2 | |
| Trifluoroacetic Acid SCHEMBL5773317 | 0.92 | CYP3A4 (0.53) | CYP3A4CYP1A2CYP2C9CYP2C19SMN1; SMN2 | |
| Trifluoroacetic Acid SCHEMBL5772978 | 0.91 | GSK3B (0.52) | CYP3A4CYP1A2CYP2C9CYP2C19SMN1; SMN2 | |
| Trifluoroacetic Acid SCHEMBL5772665 | 0.85 | NPC1 (0.52) | SMN1; SMN2MAPTLMNAHTTALDH1A1 | |
| Trifluoroacetic Acid SCHEMBL5775717 | 0.84 | GSK3B (0.44) | CYP1A2CYP2C9CYP2C19SMN1; SMN2KMT2A | |
| Trifluoroacetic Acid SCHEMBL5771354 | 0.84 | ALDH1A1 (0.49) | CYP3A4CYP1A2CYP2C9CYP2C19SMN1; SMN2 | |
| Trifluoroacetic Acid SCHEMBL5774568 | 0.84 | LMNA (0.50) | SMN1; SMN2MAPTLMNAALDH1A1SORT1 | |
| Trifluoroacetic Acid SCHEMBL5771828 | 0.83 | GSK3B (0.42) | CYP3A4CYP1A2CYP2C9CYP2C19SMN1; SMN2 | |
| SCHEMBL5775471 | 0.82 | HDAC3 (0.46) | SMN1; SMN2LMNAHTTKMT2AMEN1 | |
| Trifluoroacetic Acid SCHEMBL5771101 | 0.81 | TP53 (0.46) | CYP3A4CYP1A2CYP2C9CYP2C19SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20060084690-A1 | Isoxazole derivatives | MOMOSE YU | 2006-04-20 | — | — | US | disclosed |
| US-7022725-B2 | Isoxazole derivatives | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2006-04-04 | — | — | US | disclosed |
| US-20040048908-A1 | Isoxazole derivatives | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2004-03-11 | — | — | US | disclosed |
| EP-1340749-A1 | ISOXAZOLE DERIVATIVES | Takeda Chemical Industries, Ltd. (JP) | 2003-09-03 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060084690-A1 | Isoxazole derivatives | INSR, GPR119, INSRR | CYP3A4 39/4885CYP1A2 68/4885CYP2C9 30/4885 |
| US-20040048908-A1 | Isoxazole derivatives | GPR119, INSR, IRS1 | CYP3A4 76/4885CYP1A2 74/4885CYP2C9 45/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.