SCHEMBL5772455

SCHEMBL5772455

CCOC(=O)/C(C(=O)Cc1cc(OC(C)C)c(Cl)cc1F)=C(/N)C(F)(F)F

nearest known ligand 0.36

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
PPOX P50336 4/20 0.36
HPGD P15428 1/20 0.33
MEN1 O00255 3/20 0.33
LMNA P02545 3/20 0.33
KMT2A Q03164 3/20 0.33
MAPT P10636 2/20 0.33
NPSR1 Q6W5P4 2/20 0.33
MAP2 P11137 1/20 0.32
GAA P10253 2/20 0.32
ALDH1A1 P00352 2/20 0.31
TSHR P16473 1/20 0.31
GPR35 Q9HC97 1/20 0.31
MRGPRX4 Q96LA9 1/20 0.31
P2RX3 P56373 1/20 0.31
MAPK1 P28482 1/20 0.31
MTNR1A P48039 1/20 0.30
MTNR1B P49286 1/20 0.30
RORC P51449 1/20 0.30
CSNK2A1 P68400 1/20 0.30
KDM4E B2RXH2 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5772458 1.00 PPOX (0.36) PPOXHPGDMEN1LMNAKMT2A
SCHEMBL7942213 0.78 PPOX (0.43) PPOXHPGDMEN1LMNAKMT2A
SCHEMBL5775031 0.73 KMO (0.43) PPOXGAAP2RX3MAPK1RORC
SCHEMBL5771616 0.67 CSNK2A1 (0.41) PPOXMEN1LMNAKMT2AMAP2
SCHEMBL10364778 0.67 ALOX15 (0.39) HPGDMEN1KMT2AMAPTNPSR1
SCHEMBL10364776 0.67 ALOX15 (0.39) HPGDMEN1KMT2AMAPTNPSR1
SCHEMBL7942194 0.66 PPOX (0.43) PPOXHPGDLMNAMAPTMAP2
SCHEMBL10576902 0.66 P2RX3 (0.46) PPOXMEN1LMNAKMT2AMAPT
SCHEMBL7942796 0.66 CSNK2A1 (0.42) PPOXHPGDMEN1LMNAKMT2A
SCHEMBL5773826 0.66 CSNK2A1 (0.42) PPOXHPGDMEN1LMNAKMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0885885-B1 PYRIDONE DERIVATIVES AND HERBICIDES KUMIAI CHEMICAL INDUSTRY CO (JP) 2006-01-04 EP disclosed
US-6472348-B1 Pyridone derivatives and herbicides KUMIAI CHEMICAL INDUSTRY CO., LTD. (JP) 2002-10-29 US disclosed
US-6265349-B1 Pyridone derivatives and herbicides KUMIAI CHEMICAL INDUSTRY CO., LTD (JP) 2001-07-24 US disclosed
US-6048823-A Pyridone derivatives and herbicides KUMIAI CHEMICAL INDUSTRY CO., LTD. (JP) 2000-04-11 US disclosed
EP-0885885-A1 PYRIDONE DERIVATIVES AND HERBICIDES KumaiI Chemical Industry Co., Ltd. (JP) 1998-12-23 EP disclosed