Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD4 | P21917 | 6/20 | 0.58 |
| ▸ | DRD2 | P14416 | 4/20 | 0.58 |
| ▸ | SIGMAR1 | Q99720 | 5/20 | 0.52 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.51 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.51 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.51 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.51 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.51 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.51 |
| ▸ | CCR2 | P41597 | 1/20 | 0.49 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | ATM | Q13315 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | BCHE | P06276 | 2/20 | 0.47 |
| ▸ | ACHE | P22303 | 2/20 | 0.47 |
| ▸ | BACE1 | P56817 | 2/20 | 0.47 |
| ▸ | HTR2A | P28223 | 1/20 | 0.47 |
| ▸ | TEAD1 | P28347 | 1/20 | 0.47 |
| ▸ | S100A4 | P26447 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Trifluoroacetic Acid SCHEMBL5771823 | 0.95 | SIGMAR1 (0.58) | DRD4DRD2SIGMAR1TSHRHTT | |
| Trifluoroacetic Acid SCHEMBL5771830 | 0.93 | DRD2 (0.54) | DRD4DRD2SIGMAR1HDAC3HDAC4 | |
| SCHEMBL5773476 | 0.78 | DRD2 (0.46) | DRD4DRD2SIGMAR1HDAC3HDAC4 | |
| Trifluoroacetic Acid SCHEMBL5774584 | 0.77 | MEN1 (0.44) | DRD4DRD2HDAC3HDAC4HDAC7 | |
| Trifluoroacetic Acid SCHEMBL5774450 | 0.77 | HTT (0.40) | SIGMAR1TSHRHTTATMSMN1; SMN2 | |
| Trifluoroacetic Acid SCHEMBL5776133 | 0.77 | HTT (0.39) | HTTS100A4 | |
| Trifluoroacetic Acid SCHEMBL5773674 | 0.77 | OPRM1 (0.47) | DRD4DRD2 | |
| SCHEMBL5771825 | 0.76 | KCNH2 (0.47) | DRD4DRD2SIGMAR1BCHEACHE | |
| SCHEMBL8712569 | 0.74 | DRD4 (1.00) | DRD4DRD2HDAC3HDAC4HDAC7 | |
| SCHEMBL11576999 | 0.74 | SIGMAR1 (0.65) | DRD4DRD2SIGMAR1CCR2BCHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20060084690-A1 | Isoxazole derivatives | MOMOSE YU | 2006-04-20 | — | — | US | disclosed |
| US-7022725-B2 | Isoxazole derivatives | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2006-04-04 | — | — | US | disclosed |
| US-20040048908-A1 | Isoxazole derivatives | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2004-03-11 | — | — | US | disclosed |
| EP-1340749-A1 | ISOXAZOLE DERIVATIVES | Takeda Chemical Industries, Ltd. (JP) | 2003-09-03 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060084690-A1 | Isoxazole derivatives | INSR, GPR119, INSRR | DRD4 2268/4885DRD2 2788/4885SIGMAR1 653/4885 |
| US-20040048908-A1 | Isoxazole derivatives | GPR119, INSR, IRS1 | DRD4 2538/4885DRD2 2833/4885SIGMAR1 874/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.