Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 3/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.40 |
| ▸ | TSHR | P16473 | 2/20 | 0.40 |
| ▸ | USP2 | O75604 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | GPR6 | P46095 | 1/20 | 0.40 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.39 |
| ▸ | DPP8 | Q6V1X1 | 2/20 | 0.39 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.39 |
| ▸ | CCR3 | P51677 | 1/20 | 0.39 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.39 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.39 |
| ▸ | ATM | Q13315 | 1/20 | 0.38 |
| ▸ | FAAH | O00519 | 1/20 | 0.38 |
| ▸ | PRKAA2 | P54646 | 1/20 | 0.38 |
| ▸ | PRCP | P42785 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Trifluoroacetic Acid SCHEMBL5776822 | 0.88 | DPP8 (0.50) | HTTTSHRDPP8DPP7PRKAA2 | |
| Trifluoroacetic Acid SCHEMBL5771830 | 0.84 | DRD2 (0.54) | HTTTSHRMCHR1CCR3SIGMAR1 | |
| Trifluoroacetic Acid SCHEMBL5771823 | 0.80 | SIGMAR1 (0.58) | HTTTSHRCHRM4SIGMAR1SMN1; SMN2 | |
| SCHEMBL5774454 | 0.79 | SIGMAR1 (0.41) | LMNADPP8CCR3CHRM4SIGMAR1 | |
| Trifluoroacetic Acid SCHEMBL5774584 | 0.78 | MEN1 (0.44) | MCHR1CHRM4PRCP | |
| Trifluoroacetic Acid SCHEMBL5773774 | 0.78 | TSHR (0.41) | HTTMAPK1TSHRUSP2LMNA | |
| Trifluoroacetic Acid SCHEMBL5773674 | 0.77 | OPRM1 (0.47) | LMNA | |
| Trifluoroacetic Acid SCHEMBL5775671 | 0.77 | TSHR (0.41) | HTTMAPK1TSHRUSP2LMNA | |
| Trifluoroacetic Acid SCHEMBL5773475 | 0.77 | DRD4 (0.58) | HTTTSHRSIGMAR1SMN1; SMN2ATM | |
| Trifluoroacetic Acid SCHEMBL5773355 | 0.77 | TSHR (0.50) | HTTMAPK1TSHRUSP2LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20060084690-A1 | Isoxazole derivatives | MOMOSE YU | 2006-04-20 | — | — | US | disclosed |
| US-7022725-B2 | Isoxazole derivatives | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2006-04-04 | — | — | US | disclosed |
| US-20040048908-A1 | Isoxazole derivatives | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2004-03-11 | — | — | US | disclosed |
| EP-1340749-A1 | ISOXAZOLE DERIVATIVES | Takeda Chemical Industries, Ltd. (JP) | 2003-09-03 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060084690-A1 | Isoxazole derivatives | INSR, GPR119, INSRR | HTT 4375/4885MAPK1 1148/4885TSHR 534/4885 |
| US-20040048908-A1 | Isoxazole derivatives | GPR119, INSR, IRS1 | HTT 3773/4885MAPK1 485/4885TSHR 583/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.