Known targets — ChEMBL curated mechanism
ACEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ATP4AATP4BAXLBTKCACNA1CCACNA1DCACNA1FCACNA1SCCR5CHRM2CHRM3CPT1BCPT2DPP4DRD1DRD2EGFRERBB2ERBB4FLT3HRH1HRH3HTR1AHTR2AHTR2BHTR2CHTR4JAK1JAK2JAK3KCNH2KMT2AMAP2K1MAP2K2MEN1MLNRMPLMTORPPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PLK4PPARGRENS1PR1SLC6A2SLC6A3SLC6A4SMOTYK2atpAatpBatpCatpDatpEatpFatpFHatpGpol
The experimentally established mechanism targets of Fumaric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 known ✓ | P14416 | 10/20 | 0.45 |
| ▸ | HTR2A known ✓ | P28223 | 4/20 | 0.45 |
| ▸ | HTR2C known ✓ | P28335 | 2/20 | 0.45 |
| ▸ | HTR2B known ✓ | P41595 | 2/20 | 0.45 |
| ▸ | HTR1A known ✓ | P08908 | 2/20 | 0.43 |
| ▸ | KCNH2 known ✓ | Q12809 | 1/20 | 0.43 |
| ▸ | DRD4 | P21917 | 6/20 | 0.45 |
| ▸ | DRD3 | P35462 | 6/20 | 0.45 |
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.45 |
| ▸ | HTR7 | P34969 | 1/20 | 0.43 |
| ▸ | PARP1 | P09874 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Maleic Acid SCHEMBL5773645 | 1.00 | DRD2 (0.45) | DRD2DRD4DRD3SIGMAR1HTR2A | |
| SCHEMBL5772832 | 0.92 | SIGMAR1 (0.53) | DRD2DRD4DRD3SIGMAR1HTR2A | |
| Fumaric Acid SCHEMBL5799811 | 0.91 | DRD4 (0.47) | DRD2DRD4DRD3SIGMAR1HTR2A | |
| Maleic Acid SCHEMBL5799806 | 0.91 | DRD4 (0.47) | DRD2DRD4DRD3SIGMAR1HTR2A | |
| Maleic Acid SCHEMBL5770880 | 0.91 | SLC27A1 (0.41) | DRD2DRD4DRD3HTR2AHTR2C | |
| Fumaric Acid SCHEMBL5770886 | 0.91 | SLC27A1 (0.41) | DRD2DRD4DRD3HTR2AHTR2C | |
| SCHEMBL5772457 | 0.90 | SIGMAR1 (0.52) | DRD2DRD4DRD3SIGMAR1HTR2A | |
| SCHEMBL5776684 | 0.89 | SIGMAR1 (0.53) | DRD2DRD4DRD3SIGMAR1HTR2A | |
| SCHEMBL5776645 | 0.81 | KCNH2 (0.57) | DRD3SIGMAR1HTR1AKCNH2HTR7 | |
| SCHEMBL5775439 | 0.81 | MAPT (0.45) | DRD2DRD4DRD3SIGMAR1KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0885883-B1 | FUSED HETEROCYCLIC COMPOUNDS AND PHARMACEUTICAL APPLICATIONS THEREOF | MITSUBISHI PHARMA CORP (JP) | 2006-11-02 | — | — | EP | disclosed |
| US-6187774-B1 | N-PIPERAZINYLALKYLINDAZOLE DERIVATIVES; PSYCHOLOGICAL DISORDERS, SCHIZOPHRENIA; SIDE EFFECT REDUCTION | YOSHITOMI PHARMACEUTICAL INDUSTRIES, LTD. (JP) | 2001-02-13 | — | — | US | disclosed |
| EP-0885883-A1 | FUSED HETEROCYCLIC COMPOUNDS AND PHARMACEUTICAL APPLICATIONS THEREOF | YOSHITOMI PHARMACEUTICAL INDUSTRIES, LTD. (JP) | 1998-12-23 | — | — | EP | disclosed |