Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 9/20 | 0.43 |
| ▸ | MAPT | P10636 | 6/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | APP | P05067 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 3/20 | 0.40 |
| ▸ | HSP90AA1 | P07900 | 2/20 | 0.40 |
| ▸ | HSP90AB1 | P08238 | 2/20 | 0.40 |
| ▸ | GAA | P10253 | 2/20 | 0.40 |
| ▸ | HTT | P42858 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | THRB | P10828 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 2/20 | 0.38 |
| ▸ | POLB | P06746 | 2/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.38 |
| ▸ | PKM | P14618 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5769835 | 0.82 | ALDH1A1 (0.47) | ALDH1A1MAPTMAPK1APPHTT | |
| SCHEMBL5772244 | 0.78 | CA12 (0.38) | ALDH1A1MAPTMAPK1LMNAHSP90AA1 | |
| SCHEMBL5892600 | 0.76 | LMNA (0.47) | ALDH1A1MAPTLMNAHSP90AA1HSP90AB1 | |
| SCHEMBL5771969 | 0.75 | LMNA (0.39) | MAPTLMNAHSP90AA1HSP90AB1HTT | |
| SCHEMBL5769687 | 0.64 | CA12 (0.32) | POLB | |
| SCHEMBL28054865 | 0.64 | KMT2A (0.44) | ALDH1A1MAPTLMNAHTTMEN1 | |
| SCHEMBL5772217 | 0.64 | RAB9A (0.49) | ALDH1A1HSP90AA1HSP90AB1HTTMEN1 | |
| SCHEMBL16741170 | 0.63 | KMT2A (0.59) | ALDH1A1MAPTMAPK1HTTMEN1 | |
| SCHEMBL6763629 | 0.61 | POLB (0.63) | ALDH1A1GAAMEN1KMT2APOLB | |
| SCHEMBL16742735 | 0.60 | CXCR4 (0.50) | MAPTLMNAHTTTSHRPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7078541-B2 | Benzofuran derivatives | GALILEO PHARMACEUTICALS, INC. (US) | 2006-07-18 | — | — | US | disclosed |
| EP-1472241-A4 | CYTOPROTECTIVE BENZOFURAN DERIVATIVES | GALILEO PHARMACEUTICALS INC (US) | 2005-06-29 | — | — | EP | disclosed |
| WO-2005027900-A1 | BENZOFURAN DERIVATIVES | GALILEO PHARMACEUTICALS, INC. (US) | 2005-03-31 | — | — | WO | disclosed |
| EP-1472241-A1 | CYTOPROTECTIVE BENZOFURAN DERIVATIVES | Galileo Pharmaceuticals, Inc. (US) | 2004-11-03 | — | — | EP | disclosed |
| US-20040063975-A1 | Benzofuran derivatives | EDISON PHARMACEUTICALS, INC. | 2004-04-01 | — | — | US | disclosed |
| US-6653346-B1 | Amtiischemic and antiinflammatory agents | GALILEO PHARMACEUTICALS, INC. | 2003-11-25 | — | — | US | disclosed |
| WO-2003066618-A1 | CYTOPROTECTIVE BENZOFURAN DERIVATIVES | GALILEO PHARMACEUTICALS, INC. (US) | 2003-08-14 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040063975-A1 | Benzofuran derivatives | NDUFAB1, AIFM1, NDUFAF1 | ALDH1A1 404/4885MAPT 278/4885MAPK1 3796/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.