Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | LIPE | Q05469 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | PPARG | P37231 | 2/20 | 0.32 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.32 |
| ▸ | PPARA | Q07869 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | CYP2E1 | P05181 | 1/20 | 0.31 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.31 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL316609 | 0.68 | CYP2D6 (0.48) | CYP2D6CYP2C19ALDH1A1KDM4ESMN1; SMN2 | |
| SCHEMBL5113337 | 0.67 | CYP2D6 (0.42) | CYP2D6CYP2C19ALDH1A1KDM4ESMN1; SMN2 | |
| SCHEMBL8715074 | 0.67 | PLD1 (0.45) | CYP2D6CYP2C19ALDH1A1KDM4ESMN1; SMN2 | |
| SCHEMBL1448809 | 0.65 | CYP2D6 (0.41) | CYP2D6CYP2C19ALDH1A1KDM4ESMN1; SMN2 | |
| SCHEMBL4086997 | 0.64 | SLC6A2 (0.42) | KDM4ECYP2E1CYP3A4CYP2A6MAPT | |
| SCHEMBL1186136 | 0.64 | CYP2D6 (0.41) | CYP2D6CYP2C19ALDH1A1KDM4ESMN1; SMN2 | |
| SCHEMBL6638291 | 0.64 | ALDH1A1 (0.41) | CYP2D6CYP2C19ALDH1A1KDM4ESMN1; SMN2 | |
| SCHEMBL1185718 | 0.64 | CYP2D6 (0.44) | CYP2D6CYP2C19ALDH1A1KDM4ESMN1; SMN2 | |
| SCHEMBL9183264 | 0.63 | ALDH1A1 (0.44) | CYP2D6CYP2C19ALDH1A1KDM4ESMN1; SMN2 | |
| SCHEMBL21883942 | 0.62 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20060084690-A1 | Isoxazole derivatives | MOMOSE YU | 2006-04-20 | — | — | US | disclosed |
| US-7022725-B2 | Isoxazole derivatives | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2006-04-04 | — | — | US | disclosed |
| US-20040048908-A1 | Isoxazole derivatives | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2004-03-11 | — | — | US | disclosed |
| EP-1340749-A1 | ISOXAZOLE DERIVATIVES | Takeda Chemical Industries, Ltd. (JP) | 2003-09-03 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060084690-A1 | Isoxazole derivatives | INSR, GPR119, INSRR | CYP2D6 192/4885CYP2C19 28/4885LIPE 297/4885 |
| US-20040048908-A1 | Isoxazole derivatives | GPR119, INSR, IRS1 | CYP2D6 190/4885CYP2C19 34/4885LIPE 160/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.