Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.39 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.38 |
| ▸ | CDK8 | P49336 | 1/20 | 0.37 |
| ▸ | CDK19 | Q9BWU1 | 1/20 | 0.37 |
| ▸ | FFAR2 | O15552 | 1/20 | 0.35 |
| ▸ | IRAK4 | Q9NWZ3 | 3/20 | 0.34 |
| ▸ | CTSK | P43235 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | CBLB | Q13191 | 1/20 | 0.33 |
| ▸ | CHKA | P35790 | 1/20 | 0.32 |
| ▸ | GRM5 | P41594 | 1/20 | 0.32 |
| ▸ | JAK2 | O60674 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.32 |
| ▸ | MEF2D | Q14814 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL312511 | 0.82 | FABP4 (0.36) | FFAR2IRAK4CTSKKMT2AMEN1 | |
| SCHEMBL9928614 | 0.81 | ALDH1A1 (0.38) | CDK8CDK19FFAR2IRAK4CTSK | |
| SCHEMBL578067 | 0.81 | FFAR2 (0.38) | P2RX7FFAR2IRAK4CTSKKMT2A | |
| SCHEMBL578153 | 0.81 | C1S (0.33) | FFAR2IRAK4CTSKKMT2AMEN1 | |
| SCHEMBL2677290 | 0.81 | ATAD2 (0.43) | KMT2AMEN1ALDH1A1 | |
| Acetic Acid SCHEMBL15573175 | 0.80 | MEN1 (0.35) | CDK8CDK19FFAR2IRAK4CTSK | |
| SCHEMBL22014915 | 0.79 | CYP3A4 (0.33) | CYP3A4CYP2D6CYP2C9SCN9AIRAK4 | |
| Hydrochloric Acid SCHEMBL578561 | 0.79 | C1S (0.33) | IRAK4KMT2AMEN1 | |
| SCHEMBL21301104 | 0.77 | HSP90AA1 (0.30) | — | |
| SCHEMBL9927079 | 0.77 | CTSK (0.44) | FFAR2IRAK4CTSKKMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 78 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12180185-B2 | Compound as protein kinase inhibitor, and pharmaceutical composition comprising thereof | HK INNO.N CORPORATION (KR) | 2024-12-31 | — | — | US | claimed |
| EP-2379537-B9 | Isoxazoline derivatives and their use as pesticide | NOVARTIS AG (CH) | 2017-07-12 | — | — | EP | claimed |
| US-9044389-B2 | Isoxazoline derivatives as pesticides | NOVARTIS TIERGESUNDHEIT AG (CH) | 2015-06-02 | — | — | US | claimed |
| EP-1858854-B1 | PYRIDINE-2-CARBOXAMIDE DERIVATIVES AS MGLUR5 ANTAGONISTS | HOFFMANN LA ROCHE (CH) | 2014-05-07 | — | — | EP | claimed |
| US-20140120147-A1 | ISOXAZOLINE DERIVATIVES AS PESTICIDES | NOVARTIS AG (CH) | 2014-05-01 | — | — | US | claimed |
| US-8653116-B2 | Isoxazoline derivatives as pesticides | NOVARTIS AG (CH) | 2014-02-18 | — | — | US | claimed |
| EP-2155720-B1 | PYRROLE-2-CARBOXAMIDE DERIVATIVES AS GLUCOKINASE ACTIVATORS, THEIR PROCESS AND PHARMACEUTICAL APPLICATION | ADVINUS THERAPEUTICS PRIVATE LTD (IN) | 2013-07-17 | — | — | EP | claimed |
| US-20130131053-A1 | ISOXAZOLINE DERIVATIVES AS PESTICIDES | NOVARTIS TIERGESUNDHEIT AG (CH) | 2013-05-23 | — | — | US | claimed |
| US-8383659-B2 | Isoxazoline derivatives as pesticides | NOVARTIS AG (CH) | 2013-02-26 | — | — | US | claimed |
| EP-2379537-B1 | Isoxazoline derivatives and their use as pesticide | NOVARTIS AG (CH) | 2012-10-31 | — | — | EP | claimed |
| EP-1987003-A1 | PYRIDINE-2-CARBOXAMIDE DERIVATIVES | F.HOFFMANN-LA ROCHE AG (CH) | 2008-11-05 | — | — | EP | claimed |
| US-7414060-B2 | Pyridine-2-carboxyamide derivatives | HOFFMANN-LA ROCHE INC. (US) | 2008-08-19 | — | — | US | claimed |
| EP-1858854-A1 | PYRIDINE-2-CARBOXAMIDE DERIVATIVES AS MGLUR5 ANTAGONISTS | F. Hoffmann-La Roche AG (CH) | 2007-11-28 | — | — | EP | claimed |
| EP-1844044-A1 | THIAZOLE-4-CARBOXAMIDE DERIVATIVES AS MGLUR5 ANTAGONISTS | F.HOFFMANN-LA ROCHE AG (CH) | 2007-10-17 | — | — | EP | claimed |
| WO-2007093542-A1 | PYRIDINE-2-CARBOXAMIDE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2007-08-23 | — | — | WO | claimed |
| US-20070197553-A1 | 4-Aryl-pyridine-2-carboxyamide derivatives | HOFFMANN-LA ROCHE INC. | 2007-08-23 | — | — | US | claimed |
| WO-2006094639-A1 | PYRIDINE-2-CARBOXAMIDE DERIVATIVES AS MGLUR5 ANTAGONISTS | F.HOFFMANN-LA ROCHE AG (CH) | 2006-09-14 | — | — | WO | claimed |
| US-20060199960-A1 | e.g. 6-Methyl-3-(pyridin-3-ylamino)-pyridine-2-carboxylic acid (4-methyl-thiazol-2-yl)-amide; metabotropic glutamate receptor antagonists (mGluR); central nervous system disorders, antidepressant, anxiolytc agent; psychosis, epilepsy, schizophrenia, Alzheimer's disease, cognitive disorders | HOFFMANN-LA ROCHE INC. | 2006-09-07 | — | — | US | claimed |
| US-20060160857-A1 | Thiazole-4-carboxyamide derivatives | HOFFMANN-LA ROCHE INC. | 2006-07-20 | — | — | US | claimed |
| WO-2006074884-A1 | THIAZOLE-4-CARBOXAMIDE DERIVATIVES AS MGLUR5 ANTAGONISTS | F.HOFFMANN-LA ROCHE AG (CH) | 2006-07-20 | — | — | WO | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060160857-A1 | Thiazole-4-carboxyamide derivatives | GRM1, GRM2, GRIA4 | CYP3A4 2309/4885CYP2D6 2816/4885CYP2C9 2618/4885 |
| US-20130131053-A1 | ISOXAZOLINE DERIVATIVES AS PESTICIDES | CYP3A7, ACHE, CYP4X1 | CYP3A4 33/4885CYP2D6 125/4885CYP2C9 7/4885 |
| US-20140120147-A1 | ISOXAZOLINE DERIVATIVES AS PESTICIDES | CYP3A7, ACHE, CYP4X1 | CYP3A4 33/4885CYP2D6 125/4885CYP2C9 7/4885 |
| US-20070197553-A1 | 4-Aryl-pyridine-2-carboxyamide derivatives | GRM2, GRM1, GRM3 | CYP3A4 2111/4885CYP2D6 2466/4885CYP2C9 2802/4885 |
| US-12180185-B2 | Compound as protein kinase inhibitor, and pharmaceutical composition comprising thereof | MAP3K20, MAP3K1, MAP3K15 | CYP3A4 3519/4885CYP2D6 3728/4885CYP2C9 3066/4885 |
| US-20060199960-A1 | e.g. 6-Methyl-3-(pyridin-3-ylamino)-pyridine-2-carboxylic acid (4-methyl-thiazol-2-yl)-amide; metabotropic glutamate receptor antagonists (mGluR); central nervous system disorders, antidepressant, anxiolytc agent; psychosis, epilepsy, schizophrenia, Alzheimer's disease, cognitive disorders | GRM3, GRM2, GRM1 | CYP3A4 1098/4885CYP2D6 476/4885CYP2C9 850/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.