Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 3/20 | 0.60 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.55 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.55 |
| ▸ | PTPN6 | P29350 | 1/20 | 0.55 |
| ▸ | GLS | O94925 | 2/20 | 0.53 |
| ▸ | CETP | P11597 | 1/20 | 0.52 |
| ▸ | FPR2 | P25090 | 2/20 | 0.50 |
| ▸ | ABL1 | P00519 | 1/20 | 0.48 |
| ▸ | RIN1 | Q13671 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | PKM | P14618 | 1/20 | 0.48 |
| ▸ | YAP1 | P46937 | 1/20 | 0.48 |
| ▸ | FPR3 | P25089 | 1/20 | 0.48 |
| ▸ | NAMPT | P43490 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 2/20 | 0.47 |
| ▸ | RAB9A | P51151 | 2/20 | 0.47 |
| ▸ | MAPT | P10636 | 2/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13930870 | 0.87 | GPR119 (0.58) | GPR119PTPN2PTPN1PTPN6GLS | |
| SCHEMBL16825852 | 0.87 | FPR2 (0.63) | GPR119PTPN2PTPN1PTPN6GLS | |
| SCHEMBL13930863 | 0.86 | PTPN2 (0.57) | GPR119PTPN2PTPN1PTPN6GLS | |
| SCHEMBL13930867 | 0.86 | PTPN2 (0.57) | GPR119PTPN2PTPN1PTPN6GLS | |
| SCHEMBL13930857 | 0.86 | KDM4E (0.61) | GPR119PTPN2PTPN1PTPN6GLS | |
| SCHEMBL13930859 | 0.85 | ALDH1A1 (0.66) | GPR119PTPN2PTPN1PTPN6GLS | |
| SCHEMBL4965158 | 0.84 | L3MBTL1 (0.67) | GPR119PTPN2PTPN1PTPN6GLS | |
| SCHEMBL2316963 | 0.84 | PTPN2 (0.64) | GPR119PTPN2PTPN1PTPN6GLS | |
| SCHEMBL3637978 | 0.83 | GPR119 (0.62) | GPR119PTPN2PTPN1PTPN6GLS | |
| SCHEMBL13930876 | 0.83 | CETP (0.65) | GPR119PTPN2PTPN1PTPN6GLS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1572683-B1 | NOVEL PIPERIDINE DERIVATIVES AS MODULATORS OF CHEMOKINE RECEPTOR CCR5 | ASTRAZENECA AB (SE) | 2006-10-18 | — | — | EP | disclosed |
| US-20060069120-A1 | Novel piperidine derivaties as modulators of chemokine receptor ccr5 | ASTRAZENECA AB (SE) | 2006-03-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060069120-A1 | Novel piperidine derivaties as modulators of chemokine receptor ccr5 | CCR5, CCR2, CXCR4 | GPR119 103/4885PTPN2 3695/4885PTPN1 3246/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.