Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 3/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | DPP4 | P27487 | 7/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.41 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.41 |
| ▸ | CRHR1 | P34998 | 3/20 | 0.40 |
| ▸ | AHR | P35869 | 1/20 | 0.39 |
| ▸ | DPP8 | Q6V1X1 | 3/20 | 0.38 |
| ▸ | DPP9 | Q86TI2 | 2/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | USP2 | O75604 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5478017 | 0.81 | HSP90AA1 (0.43) | DPP4KMT2AMEN1HSP90AA1HSP90AB1 | |
| SCHEMBL25204585 | 0.73 | SMN1; SMN2 (0.34) | CYP3A4 | |
| SCHEMBL464507 | 0.72 | AHR (0.64) | HSD11B1HSP90AA1HSP90AB1CRHR1AHR | |
| SCHEMBL29624840 | 0.72 | AHR (0.64) | HSD11B1HSP90AA1HSP90AB1CRHR1AHR | |
| SCHEMBL5889678 | 0.70 | MEN1 (0.40) | HSD11B1DPP4KMT2AMEN1CRHR1 | |
| SCHEMBL3761176 | 0.68 | CRHR1 (0.53) | HSD11B1DPP4KMT2AMEN1CRHR1 | |
| SCHEMBL14744467 | 0.68 | PLA2G7 (0.66) | HSD11B1DPP4HSP90AA1HSP90AB1CRHR1 | |
| SCHEMBL14996668 | 0.68 | HSD11B1 (0.53) | HSD11B1KMT2AMEN1CRHR1 | |
| SCHEMBL5849283 | 0.67 | DPP4 (0.45) | HSD11B1LMNADPP4KMT2AHSP90AA1 | |
| SCHEMBL5847143 | 0.67 | DPP4 (0.51) | HSD11B1DPP4KMT2AMEN1HSP90AA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7074791-B2 | Pyrrolo[1,2-b]pyridazine compounds and their uses | PFIZER INC. (US) | 2006-07-11 | — | — | US | disclosed |
| EP-1622911-A2 | PYRROLO[1,2-B]PYRIDAZINE COMPOUNDS AND THEIR USE AS CRF-1 RECEPTOR ANTAGONISTS | Pharmacia & Upjohn Company LLC (US) | 2006-02-08 | — | — | EP | disclosed |
| EP-1615929-A1 | PYRROLO [1,2-B] PYRIDAZINE COMPOUNDS AND THEIR USES | Pharmacia & Upjohn Company LLC (US) | 2006-01-18 | — | — | EP | disclosed |
| US-20040242587-A1 | Pyrrolo[1,2-b]pyridazine compounds | PFIZER INC | 2004-12-02 | — | — | US | disclosed |
| WO-2004099213-A2 | PYRROLO (1,2-B) PYRIDAZINE COMPOUNDS AND THEIR USE AS CRF-1 RECEPTOR ANTAGONISTS | PHARMACIA & UPJOHN COMPANY LLC (US) | 2004-11-18 | — | — | WO | disclosed |
| WO-2004092176-A1 | PYRROLO[1,2-B]PYRIDAZINE COMPOUNDS AND THEIR USES | PHARMACIA & UPJOHN COMPANY LLC (US) | 2004-10-28 | — | — | WO | disclosed |
| US-20040138221-A1 | Pyrrrolo[1,2-b]pyridazine compounds and their uses | PFIZER INC. | 2004-07-15 | — | — | US | disclosed |
| WO-2004035586-A1 | PYRROLO[1,2-B]PYRIDAZINE COMPOUNDS AND THEIR USES | PHARMACIA & UPJOHN COMPANY LLC (US) | 2004-04-29 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040138221-A1 | Pyrrrolo[1,2-b]pyridazine compounds and their uses | CRHR1, CRHR2, MC2R | HSD11B1 329/4885LMNA 4485/4885DPP4 1497/4885 |
| US-20040242587-A1 | Pyrrolo[1,2-b]pyridazine compounds | CRHR1, CRHR2, CRH | HSD11B1 186/4885LMNA 4401/4885DPP4 1351/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.