Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 2/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.48 |
| ▸ | MEN1 | O00255 | 4/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | CTPS1 | P17812 | 1/20 | 0.41 |
| ▸ | SLC40A1 | Q9NP59 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5693072 | 0.83 | HSD11B1 (0.76) | HSD11B1KMT2AMEN1POLBALDH1A1 | |
| SCHEMBL5798138 | 0.80 | ALDH1A1 (0.53) | HSD11B1KMT2AMEN1POLBALDH1A1 | |
| SCHEMBL5797968 | 0.78 | KMT2A (0.68) | HSD11B1KMT2AMEN1POLBALDH1A1 | |
| SCHEMBL27650160 | 0.78 | KMT2A (0.73) | HSD11B1KMT2AMEN1POLBALDH1A1 | |
| SCHEMBL6026445 | 0.78 | PFKFB3 (0.56) | HSD11B1KMT2AMEN1POLBL3MBTL1 | |
| SCHEMBL5794528 | 0.77 | PKM (0.53) | HSD11B1KMT2AMEN1POLBALDH1A1 | |
| SCHEMBL3926489 | 0.76 | PFKFB3 (0.45) | HSD11B1KMT2AMEN1ALDH1A1LMNA | |
| SCHEMBL5806893 | 0.76 | CDK5 (0.49) | HSD11B1KMT2AMEN1POLBALDH1A1 | |
| SCHEMBL3925143 | 0.76 | PFKFB3 (0.44) | HSD11B1KMT2AMEN1ALDH1A1CTPS1 | |
| SCHEMBL5811010 | 0.75 | KMT2A (0.61) | HSD11B1KMT2AMEN1POLBALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2006050908-A1 | INHIBITORS OF 11ΒΕΤΑ-HYDROXY STEROID DEHYDROGENASE TYPE 1 (11BETA-HSD1) | EVOTEC AG (DE) | 2006-05-18 | — | — | WO | disclosed |