Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.50 |
| ▸ | GAA | P10253 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.48 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | RXRA | P19793 | 1/20 | 0.44 |
| ▸ | CES2 | O00748 | 1/20 | 0.44 |
| ▸ | CES1 | P23141 | 1/20 | 0.44 |
| ▸ | NQO2 | P16083 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | GSK3B | P49841 | 1/20 | 0.42 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.42 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.42 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.42 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.42 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.42 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.42 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11998008 | 0.88 | RXRA (0.47) | KDM4EGAASMN1; SMN2POLBRXRA | |
| SCHEMBL11074258 | 0.87 | KDM4E (0.40) | KDM4EGAAALDH1A1ABCG2SMN1; SMN2 | |
| SCHEMBL29060616 | 0.83 | GAA (0.47) | KDM4EGAAALDH1A1ABCG2SMN1; SMN2 | |
| SCHEMBL846394 | 0.83 | KMT2A (0.58) | KDM4EGAAALDH1A1ABCG2SMN1; SMN2 | |
| SCHEMBL9033112 | 0.81 | ALOX5 (0.49) | ALDH1A1SMN1; SMN2KMT2APOLB | |
| SCHEMBL9718856 | 0.81 | BACE1 (0.45) | KDM4EGAAALDH1A1ABCG2KMT2A | |
| SCHEMBL10497616 | 0.81 | KDM4E (0.49) | KDM4EGAAALDH1A1ABCG2SMN1; SMN2 | |
| SCHEMBL333513 | 0.81 | GSK3B (0.66) | KDM4EGAAALDH1A1ABCG2SMN1; SMN2 | |
| SCHEMBL29588852 | 0.80 | CES2 (0.67) | ALDH1A1ABCG2SMN1; SMN2KMT2APOLB | |
| SCHEMBL1305114 | 0.80 | CES2 (0.67) | ALDH1A1ABCG2SMN1; SMN2KMT2APOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7122573-B2 | Analogs of green tea polyphenols as chemotherapeutic and chemopreventive agents | SRI INTERNATIONAL (US) | 2006-10-17 | — | — | US | disclosed |
| US-7109236-B2 | Analogs of green tea polyphenols as chemotherapeutic and chemopreventive agents | SRI INTERNATIONAL (US) | 2006-09-19 | — | — | US | disclosed |
| EP-1581512-A2 | ANALOGS OF GREEN TEA POLYPHENOLS AS CHEMOTHERAPEUTIC AND CHEMOPREVENTIVE AGENTS | SRI INTERNATIONAL (US) | 2005-10-05 | — | — | EP | disclosed |
| US-20040192723-A1 | Analogs of green tea polyphenols as chemotherapeutic and chemopreventive agents | SRI INTERNATIONAL | 2004-09-30 | — | — | US | disclosed |
| WO-2004052873-A9 | ANALOGS OF GREEN TEA POLYPHENOLS AS CHEMOTHERAPEUTIC AND CHEMOPREVENTIVE AGENTS | STANFORD RES INST INT (US) | 2004-08-12 | — | — | WO | disclosed |
| WO-2004052873-A2 | ANALOGS OF GREEN TEA POLYPHENOLS AS CHEMOTHERAPEUTIC AND CHEMOPREVENTIVE AGENTS | SRI INTERNATIONAL (US) | 2004-06-24 | — | — | WO | disclosed |
| US-20040110790-A1 | Analogs of green tea polyphenols as chemotherapeutic and chemopreventive agents | SRI INTERNATIONAL | 2004-06-10 | — | — | US | disclosed |
| US-RE37729-E1 | 4-Heteroaryl-1-piperidinealkylamines and derivatives thereof and their therapeutic utility | AVENTIS PHARMACEUTICALS INC. | 2002-06-04 | — | — | US | disclosed |
| US-6251907-B1 | 1-(aryloxyalkyl)-4-(heteroaryl) piperazines and related compounds useful as antipsychotics and analgesics | AVENTIS PHARMACEUTICALS INC. | 2001-06-26 | — | — | US | disclosed |
| CN-1274354-A | Robustaflavone, intermediates and analogues and method for prepn. method | MEDICHEM RES INC (US) | 2000-11-22 | — | — | CN | disclosed |
| CN-1148593-A | Production method for chromone derivative and its medicinal composition | KUREHA CHEMICAL IND CO LTD (JP) | 1997-04-30 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040192723-A1 | Analogs of green tea polyphenols as chemotherapeutic and chemopreventive agents | TEAD4, TEAD3, TEAD1 | KDM4E 1321/4885GAA 2353/4885ALDH1A1 107/4885 |
| US-20040110790-A1 | Analogs of green tea polyphenols as chemotherapeutic and chemopreventive agents | TEAD4, TEAD3, TEAD1 | KDM4E 1321/4885GAA 2353/4885ALDH1A1 107/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.