Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PKM | P14618 | 1/20 | 0.42 |
| ▸ | BRD4 | O60885 | 3/20 | 0.41 |
| ▸ | PARG | Q86W56 | 2/20 | 0.40 |
| ▸ | DCK | P27707 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | HTR1A | P08908 | 3/20 | 0.39 |
| ▸ | HTR7 | P34969 | 3/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | RECQL | P46063 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | KIT | P10721 | 1/20 | 0.38 |
| ▸ | DRD2 | P14416 | 1/20 | 0.38 |
| ▸ | HTR6 | P50406 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | NAT1 | P18440 | 1/20 | 0.38 |
| ▸ | MAP2K7 | O14733 | 1/20 | 0.38 |
| ▸ | MAP2K4 | P45985 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5849888 | 0.95 | MMP1 (0.41) | PKMBRD4PARGDCKKMT2A | |
| SCHEMBL5849713 | 0.88 | PKM (0.46) | PKMPARGKMT2ATDP1HTR1A | |
| SCHEMBL5848446 | 0.87 | MAPK1 (0.42) | PKMBRD4PARGKMT2ATDP1 | |
| SCHEMBL5848008 | 0.83 | LMNA (0.44) | PKMBRD4PARGHTR1AHTR7 | |
| SCHEMBL5847978 | 0.81 | PTGS2 (0.41) | BRD4NAT1LMNAGAA | |
| SCHEMBL5848641 | 0.81 | MAP2K4 (0.48) | PKMKMT2ATDP1HTR1AHTR7 | |
| SCHEMBL5849863 | 0.81 | ALDH1A1 (0.53) | PKMKMT2AKDM4ERECQLSMN1; SMN2 | |
| SCHEMBL5850188 | 0.76 | MMP1 (0.41) | BRD4NAT1LMNAGAA | |
| SCHEMBL5848614 | 0.68 | CA12 (0.40) | BRD4KDM4ELMNAGAA | |
| SCHEMBL28713447 | 0.68 | SMN1; SMN2 (0.63) | PKMPARGDCKKMT2ATDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7112605-B2 | Sulfonyl-containing 3,4-diaryl-3-pyrrolin-2-ones, preparation method, and medical use thereof | Research Institute of Materia Medica Chinese Acadamy of Medical Sciences (CN) | 2006-09-26 | — | — | US | claimed |