Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | PKM | P14618 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | CA12 | O43570 | 2/20 | 0.42 |
| ▸ | CA9 | Q16790 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | CA7 | P43166 | 1/20 | 0.42 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | CA1 | P00915 | 1/20 | 0.41 |
| ▸ | CA2 | P00918 | 1/20 | 0.41 |
| ▸ | MMP2 | P08253 | 2/20 | 0.40 |
| ▸ | CASP1 | P29466 | 1/20 | 0.40 |
| ▸ | ADAMTS4 | O75173 | 1/20 | 0.40 |
| ▸ | MMP13 | P45452 | 1/20 | 0.40 |
| ▸ | MMP14 | P50281 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5853427 | 0.88 | PKM (0.56) | LMNAPKMALDH1A1CA12CA9 | |
| SCHEMBL5851824 | 0.79 | ATM (0.52) | LMNAALDH1A1MAPTGAAMMP2 | |
| SCHEMBL6773139 | 0.75 | PRSS1 (0.50) | LMNAALDH1A1MAPTMAPK1L3MBTL1 | |
| SCHEMBL8577697 | 0.72 | RAB9A (0.64) | LMNAALDH1A1CA12CA9MAPT | |
| SCHEMBL27245265 | 0.72 | LMNA (0.59) | LMNAPKMALDH1A1MAPTGAA | |
| SCHEMBL13323438 | 0.72 | ALDH1A1 (0.61) | LMNAALDH1A1MAPTMAPK1L3MBTL1 | |
| SCHEMBL7471734 | 0.72 | PKM (0.72) | LMNAPKMALDH1A1MAPTMAPK1 | |
| SCHEMBL8574580 | 0.71 | RAB9A (0.65) | LMNAALDH1A1CA12CA9L3MBTL1 | |
| SCHEMBL2705227 | 0.71 | ALDH1A1 (0.56) | LMNAPKMALDH1A1MAPK1KMT2A | |
| SCHEMBL19743611 | 0.71 | LMNA (0.57) | LMNAPKMALDH1A1CA12CA9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7057036-B2 | Pyrrolothiazine and pyrrolothiazepine compounds having serotonin-2 receptor antagonistic and alpha-1-blocking action | DAIICHI SUNTORY PHARMA CO., LTD. (JP) | 2006-06-06 | — | — | US | disclosed |
| US-20050038242-A2 | PYRROLOTHIAZINE AND PYRROLOTHIAZEPHINE COMPOUNDS HAVING SEROTONIN-2 RECEPTOR ANTAGONISTIC AND ALPHA-1-BLOCKING ACTION | DAIICHI SUNTORY PHARMA CO., LTD. (JP) | 2005-02-17 | — | — | US | disclosed |
| US-20040127705-A1 | Pyrrolothiazine and pyrrolothiazepine compounds having serotonin-2 receptor antagonistic and alpha-1-blocking action | DAIICHI PHARMACEUTICAL CO., LTD. (JP) | 2004-07-01 | — | — | US | disclosed |
| US-6624314-B2 | A pyrrolesulfonamide derivative or salt, useful for treating circulatory diseases such as ischemic heart diseases, cerebrovascular disturbances and peripheral circulatory disturtances | DAIICHI SUNTORY PHARMA CO., LTD. (JP) | 2003-09-23 | — | — | US | disclosed |
| US-6583296-B2 | Pyrrolothiazine and pyrrolothiazepine compounds having serotonin-2 receptor antagonistic and α-1-blocking action | DAIICHI SUNTORY PHARMA CO., LTD. (JP) | 2003-06-24 | — | — | US | disclosed |
| US-20020137928-A1 | Pyrrolothiazine and pyrrolothiazepine compounds having serotonin-2 receptor antagonistic and alpha-1-blocking action | SUNTORY LIMITED (JP) | 2002-09-26 | — | — | US | disclosed |
| US-20020040017-A1 | Pyrrolothiazine and pyrrolothiazepine compounds having serotonin-2 receptor antagonistic and alpha-1-blocking action | SUNTORY LIMITED (JP) | 2002-04-04 | — | — | US | disclosed |
| US-6331623-B1 | Pyrrolothiazine and pyrrolothiazepine compounds having serotonin-2 receptor antagonistic and alpha-1-blocking action | SUNTORY LIMITED (JP) | 2001-12-18 | — | — | US | disclosed |
| US-6271223-B1 | CARDIOVASCULAR DISORDERS | SUNTORY LIMITED (JP) | 2001-08-07 | — | — | US | disclosed |
| EP-0970089-A2 | PYRROLOTHIAZINE AND PYRROLOTHIAZEPINE COMPOUNDS HAVING SEROTONIN-2 RECEPTOR ANTAGONISTIC AND ALPHA-1-BLOCKING ACTION | SUNTORY LIMITED (JP) | 2000-01-12 | — | — | EP | disclosed |
| EP-0970088-A2 | PYRROLOTHIAZINE AND PYRROLOTHIAZEPINE COMPOUNDS HAVING SEROTONIN-2 RECEPTOR ANTAGONISTIC AND ALPHA1-BLOCKING ACTION | SUNTORY LIMITED (JP) | 2000-01-12 | — | — | EP | disclosed |
| WO-1999033840-A2 | PYRROLOTHIAZINE AND PYRROLOTHIAZEPINE COMPOUNDS HAVING SEROTONIN-2 RECEPTOR ANTAGONISTIC AND ALPHA1-BLOCKING ACTION | SUNTORY LIMITED (JP) | 1999-07-08 | — | — | WO | disclosed |
| WO-1999033841-A2 | PYRROLOTHIAZINE AND PYRROLOTHIAZEPINE COMPOUNDS HAVING SEROTONIN-2 RECEPTOR ANTAGONISTIC AND ALPHA-1-BLOCKING ACTION | SUNTORY LIMITED (JP) | 1999-07-08 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050038242-A2 | PYRROLOTHIAZINE AND PYRROLOTHIAZEPHINE COMPOUNDS HAVING SEROTONIN-2 RECEPTOR ANTAGONISTIC AND ALPHA-1-BLOCKING ACTION | HTR1D, HTR1E, TPH1 | LMNA 4434/4885PKM 2292/4885ALDH1A1 1544/4885 |
| US-20040127705-A1 | Pyrrolothiazine and pyrrolothiazepine compounds having serotonin-2 receptor antagonistic and alpha-1-blocking action | TPH1, HTR1A, HTR1D | LMNA 1497/4885PKM 1320/4885ALDH1A1 1916/4885 |
| US-20020040017-A1 | Pyrrolothiazine and pyrrolothiazepine compounds having serotonin-2 receptor antagonistic and alpha-1-blocking action | TPH1, HTR1A, HTR1D | LMNA 1549/4885PKM 1290/4885ALDH1A1 1887/4885 |
| US-20020137928-A1 | Pyrrolothiazine and pyrrolothiazepine compounds having serotonin-2 receptor antagonistic and alpha-1-blocking action | HTR2C, HTR1A, HTR1D | LMNA 1137/4885PKM 1389/4885ALDH1A1 1867/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.