Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CLK1 | P49759 | 3/20 | 0.38 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.38 |
| ▸ | AXL | P30530 | 1/20 | 0.37 |
| ▸ | EP300 | Q09472 | 1/20 | 0.37 |
| ▸ | KAT2B | Q92831 | 1/20 | 0.37 |
| ▸ | KAT8 | Q9H7Z6 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | RAD52 | P43351 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 2/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | EGFR | P00533 | 2/20 | 0.34 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.33 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17697140 | 0.77 | HDAC8 (0.33) | AXLEP300KAT2BKAT8KDM4E | |
| SCHEMBL12795245 | 0.75 | ACHE (0.34) | AXLEP300KAT2BKAT8KDM4E | |
| SCHEMBL4025561 | 0.71 | KDM4E (0.45) | KDM4EPOLBHTTRAD52GAA | |
| SCHEMBL17303505 | 0.71 | HTR6 (0.33) | — | |
| SCHEMBL15935237 | 0.71 | XPO1 (0.31) | — | |
| SCHEMBL1652259 | 0.67 | AXL (0.45) | CLK1DYRK1AAXLEP300KAT2B | |
| SCHEMBL31587098 | 0.67 | ALDH1A1 (0.55) | DYRK1AAXLEP300KAT2BKAT8 | |
| SCHEMBL9722741 | 0.65 | MAPT (0.43) | KDM4ERAD52GAALMNACYP3A4 | |
| SCHEMBL11200595 | 0.64 | GPR3 (0.41) | AXLEP300KAT2BKAT8KDM4E | |
| SCHEMBL2879912 | 0.64 | NCF1 (0.57) | CLK1DYRK1AAXLEP300KAT2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3063142-B1 | INHIBITORS OF THE RENAL OUTER MEDULLARY POTASSIUM CHANNEL | MERCK SHARP & DOHME (US) | 2019-01-30 | — | — | EP | disclosed |
| US-9951052-B2 | Inhibitors of the renal outer medullary potassium channel | MERCK SHARP & DOHME CORP. (US) | 2018-04-24 | — | — | US | disclosed |
| US-20160257670-A1 | Inhibitors of the Renal Outer Medullary Potassium Channel | MERCK SHARP & DOHME CORP. (US) | 2016-09-08 | — | — | US | disclosed |
| US-7138539-B2 | Colorant compounds containing copolymerizable vinyl groups | EASTMAN CHEMICAL COMPANY (US) | 2006-11-21 | — | — | US | disclosed |
| US-7060829-B2 | Colorant compounds containing copolymerizable vinyl groups | EASTMAN CHEMICAL COMPANY (US) | 2006-06-13 | — | — | US | disclosed |
| US-7030244-B2 | Colorant compounds containing copolymerizable vinyl groups | EASTMAN CHEMICAL COMPANY (US) | 2006-04-18 | — | — | US | disclosed |
| US-20060052589-A1 | Colorant compounds containing copolymerizable vinyl groups | CYR MICHAEL J | 2006-03-09 | — | — | US | disclosed |
| US-6727372-B2 | PHOTOPOLYMERIZATION; ADDITION POLYMERS | EASTMAN CHEMICAL COMPANY | 2004-04-27 | — | — | US | disclosed |
| US-20040059124-A1 | Colorant compounds containing copolymerizable vinyl groups | CYR MICHAEL JOHN (US) | 2004-03-25 | — | — | US | disclosed |
| US-20020132874-A1 | Colorant compounds containing copolymerizable vinyl groups | EASTMAN CHEMICAL COMPANY | 2002-09-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040059124-A1 | Colorant compounds containing copolymerizable vinyl groups | ALOX5, ALAD, EED | CLK1 4359/4885DYRK1A 4435/4885AXL 2790/4885 |
| US-20160257670-A1 | Inhibitors of the Renal Outer Medullary Potassium Channel | KCNJ11, KCNJ1, KCNJ2 | CLK1 642/4885DYRK1A 2326/4885AXL 2321/4885 |
| US-20060052589-A1 | Colorant compounds containing copolymerizable vinyl groups | ALOX5, ALAD, EED | CLK1 4359/4885DYRK1A 4435/4885AXL 2790/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.