SCHEMBL5865018

SCHEMBL5865018

[CH2]CCCO[Si](c1ccccc1)(c1ccccc1)C(C)(C)C

nearest known ligand 0.44

Predicted protein targets (top 5)

geneUniProtsupporting neighboursconfidence
SMYD2 Q9NRG4 3/20 0.38
CYP3A4 P08684 1/20 0.38
HTT P42858 1/20 0.38
SMN1; SMN2 Q16637 1/20 0.38
DUT P33316 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29142571 0.93 SMYD2 (0.37) SMYD2CYP3A4HTTSMN1; SMN2
SCHEMBL28550615 0.88 SMYD2 (0.40) SMYD2CYP3A4HTTSMN1; SMN2
SCHEMBL702653 0.84 LTA4H (0.42) SMYD2CYP3A4HTTSMN1; SMN2
SCHEMBL2508018 0.84 SMYD2 (0.39) SMYD2CYP3A4HTTSMN1; SMN2DUT
SCHEMBL24312364 0.83 SMN1; SMN2 (0.40) SMYD2CYP3A4HTTSMN1; SMN2
SCHEMBL4266551 0.83 SMYD2 (0.38) SMYD2CYP3A4HTTSMN1; SMN2DUT
SCHEMBL5488886 0.83 LTA4H (0.42) SMYD2CYP3A4HTTSMN1; SMN2
SCHEMBL440160 0.83 SMYD2 (0.38) SMYD2CYP3A4HTTSMN1; SMN2
SCHEMBL2818126 0.83 SMN1; SMN2 (0.38) SMYD2CYP3A4HTTSMN1; SMN2
SCHEMBL6446538 0.83 SMYD2 (0.38) SMYD2CYP3A4HTTSMN1; SMN2DUT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20230373900-A1 CYCLOPROPENIUM COMPOUNDS, PROCESS FOR THEIR PREPARATION AND USE FUNDACIÓ INSTITUT CATALÀ D'INVESTIGACIÓ QUÍMICA (ES) 2023-11-23 US claimed
EP-4279480-A1 CYCLOPROPENIUM COMPOUNDS, PROCESS FOR THEIR PREPARATION AND USE Fundació Institut Català d'Investigació Química (ES) 2023-11-22 EP claimed
US-20230373900-A1 CYCLOPROPENIUM COMPOUNDS, PROCESS FOR THEIR PREPARATION AND USE FUNDACIÓ INSTITUT CATALÀ D'INVESTIGACIÓ QUÍMICA (ES) 2023-11-23 US disclosed
EP-4279480-A1 CYCLOPROPENIUM COMPOUNDS, PROCESS FOR THEIR PREPARATION AND USE Fundació Institut Català d'Investigació Química (ES) 2023-11-22 EP disclosed
CN-109641931-B Method for synthesizing ribonucleic acid H-phosphate monomer and oligonucleotide synthesis using the same 基因设计有限公司 2022-10-18 CN disclosed
US-11174279-B2 Method for synthesizing ribonucleic acid H-phosphonate monomer, and oligonucleotide synthesis in which said monomer is used NATIONAL INSTITUTE OF ADVANCED INDUSTRIAL SCIENCE AND TECHNOLOGY (JP) 2021-11-16 US disclosed
US-20200331945-A1 METHOD FOR SYNTHESIZING RIBONUCLEIC ACID H-PHOSPHONATE MONOMER, AND OLIGONUCLEOTIDE SYNTHESIS IN WHICH SAID MONOMER IS USED NATIONAL INSTITUTE OF ADVANCED INDUSTRIAL SCIENCE AND TECHNOLOGY (JP) 2020-10-22 US disclosed
EP-3473637-A1 METHOD FOR SYNTHESIZING RIBONUCLEIC ACID H-PHOSPHONATE MONOMER, AND OLIGONUCLEOTIDE SYNTHESIS IN WHICH SAID MONOMER IS USED Genedesign, Inc. (JP) 2019-04-24 EP disclosed
US-7125999-B2 Process for producing organotitanium compound and process for addition reaction NISSAN CHEMICAL INDUSTIES, LTD. (JP) 2006-10-24 US disclosed
US-20040167344-A1 Process for producing organotitanium compound and process for addition reaction FUMIE SATO 2004-08-26 US disclosed
US-6743916-B2 REACTING AN ACETYLENE COMPOUND IN THE PRESENCE OF A TITANIUM COMPOUND AND GRIGNARD REAGENT TO OBTAIN ORGANOTITANIUM COMPOUND Sato, Fumie (JP) 2004-06-01 US disclosed
US-20030096996-A1 Process for producing organotitanium compound and process for addition reaction NISSAN CHEMICAL INDUSTRIES, LTD. (JP) 2003-05-22 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20040167344-A1 Process for producing organotitanium compound and process for addition reaction ZYX, H1-4, GRIA4 SMYD2 3137/4885CYP3A4 64/4885HTT 3944/4885
US-20200331945-A1 METHOD FOR SYNTHESIZING RIBONUCLEIC ACID H-PHOSPHONATE MONOMER, AND OLIGONUCLEOTIDE SYNTHESIS IN WHICH SAID MONOMER IS USED RNGTT, RNASEL, NSUN3 SMYD2 1177/4885CYP3A4 4085/4885HTT 371/4885
US-20030096996-A1 Process for producing organotitanium compound and process for addition reaction ZYX, H1-4, GRIA4 SMYD2 3137/4885CYP3A4 64/4885HTT 3944/4885
US-11174279-B2 Method for synthesizing ribonucleic acid H-phosphonate monomer, and oligonucleotide synthesis in which said monomer is used RNGTT, RNASEL, NSUN3 SMYD2 1177/4885CYP3A4 4085/4885HTT 371/4885
US-20230373900-A1 CYCLOPROPENIUM COMPOUNDS, PROCESS FOR THEIR PREPARATION AND USE DHPS, CYP11B2, PIN1 SMYD2 1210/4885CYP3A4 22/4885HTT 1719/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.