Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 11/20 | 0.42 |
| ▸ | HSP90AA1 | P07900 | 8/20 | 0.42 |
| ▸ | HTT | P42858 | 6/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 5/20 | 0.42 |
| ▸ | LMNA | P02545 | 5/20 | 0.42 |
| ▸ | MAPT | P10636 | 4/20 | 0.42 |
| ▸ | SLC6A2 | P23975 | 3/20 | 0.42 |
| ▸ | IDO1 | P14902 | 2/20 | 0.42 |
| ▸ | HSP90AB1 | P08238 | 2/20 | 0.42 |
| ▸ | BRD4 | O60885 | 2/20 | 0.42 |
| ▸ | METAP2 | P50579 | 2/20 | 0.42 |
| ▸ | MPI | P34949 | 1/20 | 0.42 |
| ▸ | METAP1 | P53582 | 1/20 | 0.42 |
| ▸ | PSMB5 | P28074 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.41 |
| ▸ | NPC1 | O15118 | 4/20 | 0.41 |
| ▸ | RAB9A | P51151 | 4/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 5/20 | 0.40 |
| ▸ | MEN1 | O00255 | 4/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5865707 | 0.81 | NSD2 (0.42) | HSP90AA1HTTL3MBTL1LMNAMAPT | |
| SCHEMBL5357007 | 0.78 | HTT (0.41) | KDM4EHTTLMNAIDO1MPI | |
| SCHEMBL5865477 | 0.70 | MAPT (0.52) | KDM4EHSP90AA1HTTL3MBTL1LMNA | |
| SCHEMBL5369195 | 0.69 | PRKD1 (0.42) | KDM4EHSP90AA1HTTL3MBTL1LMNA | |
| SCHEMBL5365445 | 0.69 | DRD2 (0.37) | DRD2 | |
| SCHEMBL13349977 | 0.68 | PARP1 (0.40) | HTTLMNADRD2 | |
| SCHEMBL170139 | 0.67 | ALDH1A1 (0.59) | KDM4EHSP90AA1HTTL3MBTL1LMNA | |
| SCHEMBL1389187 | 0.67 | KDM4E (0.52) | KDM4EHSP90AA1HTTL3MBTL1LMNA | |
| SCHEMBL18403202 | 0.67 | PNMT (0.53) | KDM4EHTTLMNAMAPTIDO1 | |
| SCHEMBL13154679 | 0.67 | LMNA (0.52) | KDM4EHSP90AA1HTTL3MBTL1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7064117-B2 | Anti-cancer 2,3-dihydro-1H-pyrrolo[3,2-f]quinoline complexes of cobalt and chromium | AUCKLAND UNISERVICES LIMITED (NZ) | 2006-06-20 | — | — | US | disclosed |
| US-20050038249-A1 | Anti-cancer 2,3-dihydro-1H-pyrrole[3,2-f] quinoline compolexes of cobalt and chromium | AUCKLAND UNISERVICES LIMITED (NZ) | 2005-02-17 | — | — | US | disclosed |
| US-20040138195-A1 | Anti-cancer 2,3-dihydro-1h-pyrrolo[3,2-f[quinoline complexes of cobalt and chromium | AUCKLAND UNISERVICES LIMITED (NZ) | 2004-07-15 | — | — | US | disclosed |
| EP-1363908-A4 | ANTI-CANCER 2,3-DIHYDRO-1H-PYRROLO 3,2-f]QUINOLINE COMPLEXES OF COBALT AND CHROMIUM | AUCKLAND UNISERVICES LTD (NZ) | 2004-05-06 | — | — | EP | disclosed |
| EP-1363908-A1 | ANTI-CANCER 2,3-DIHYDRO-1H-PYRROLO 3,2-f]QUINOLINE COMPLEXES OF COBALT AND CHROMIUM | Auckland Uniservices Limited (NZ) | 2003-11-26 | — | — | EP | disclosed |
| WO-2002059122-A1 | ANTI-CANCER 2,3-DIHYDRO-1H-PYRROLO[3,2-f]QUINOLINE COMPLEXES OF COBALT AND CHROMIUM | AUCKLAND UNISERVICES LIMITED (NZ) | 2002-08-01 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040138195-A1 | Anti-cancer 2,3-dihydro-1h-pyrrolo[3,2-f[quinoline complexes of cobalt and chromium | IDH1, HIF1AN, CA2 | KDM4E 784/4885HSP90AA1 3362/4885HTT 4474/4885 |
| US-20050038249-A1 | Anti-cancer 2,3-dihydro-1H-pyrrole[3,2-f] quinoline compolexes of cobalt and chromium | CA2, HIF1AN, PPOX | KDM4E 331/4885HSP90AA1 3153/4885HTT 4474/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.