Sugi Predict

Sugi Predict / Compounds / SCHEMBL5866532

SCHEMBL5866532

SCHEMBL5866532

CCOC(=O)C(C)C(=O)c1ccccc1

nearest known ligand 0.59

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ KMT2A Q03164 3/20 0.57
▸ MEN1 O00255 2/20 0.57
▸ NPC1 O15118 1/20 0.57
▸ PGR P06401 1/20 0.51
▸ ADRA2A P08913 1/20 0.51
▸ ADRA2B P18089 1/20 0.51
▸ HTR2A P28223 1/20 0.51
▸ HRH1 P35367 1/20 0.51
▸ KCNH2 Q12809 1/20 0.51
▸ PIN1 Q13526 1/20 0.50
▸ ALDH1A1 P00352 3/20 0.49
▸ MAPT P10636 1/20 0.49
▸ CA12 O43570 2/20 0.48
▸ CA1 P00915 2/20 0.48
▸ CA2 P00918 2/20 0.48
▸ CA9 Q16790 2/20 0.48
▸ MMP8 P22894 1/20 0.46
▸ L3MBTL1 Q9Y468 2/20 0.46
▸ SMN1; SMN2 Q16637 2/20 0.46
▸ HTT P42858 1/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL32688319 0.86 MEN1 (0.48) KMT2AMEN1NPC1ALDH1A1L3MBTL1
SCHEMBL28119887 0.85 LMNA (0.47) KMT2AMEN1ADRA2BALDH1A1CA12
SCHEMBL1741190 0.84 ALDH1A1 (0.53) KMT2AMEN1NPC1PGRADRA2A
SCHEMBL11250823 0.84 MEN1 (0.56) KMT2AMEN1NPC1PGRADRA2A
SCHEMBL28226195 0.83 NPC1 (0.59) KMT2AMEN1NPC1PGRADRA2A
SCHEMBL2098734 0.83 NPC1 (0.59) KMT2AMEN1NPC1PGRADRA2A
SCHEMBL27715083 0.83 NPC1 (0.59) KMT2AMEN1NPC1PGRADRA2A
SCHEMBL15805596 0.83 TSHR (0.51) KMT2APGRADRA2AADRA2BHTR2A
SCHEMBL3949462 0.83 KDM4E (0.50) KMT2AMEN1NPC1ALDH1A1MAPT
SCHEMBL16050447 0.82 MEN1 (0.54) KMT2AMEN1NPC1PGRADRA2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 90 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-112778133-A high-pH-value chrome tanning auxiliary agent containing polyfunctional group structure and preparation method and application thereof 南京工业大学 2021-05-11 — — CN claimed
US-12378200-B2 Oxopyridine derivatives useful as aminocarboxymuconate semialdehyde decarboxylase (ACMSD) inhibitors ORSOBIO, INC. (US) 2025-08-05 — — US disclosed
US-20250145572-A1 Aminocarboxymuconate Semialdehyde Decarboxylase (ACMSD) Inhibitors ORSOBIO INC (US) 2025-05-08 — — US disclosed
US-20240059657-A1 OXOPYRIDINE DERIVATIVES USEFUL AS AMINOCARBOXYMUCONATE SEMIALDEHYDE DECARBOXYLASE (ACMSD) INHIBITORS OrsoBio Inc. 2024-02-22 — — US disclosed
US-11780812-B2 Oxopyridine derivatives useful as aminocarboxymuconate semialdehyde decarboxylase (ACMSD) inhibitors ORSOBIO, INC. (US) 2023-10-10 — — US disclosed
US-11780812-B2 Oxopyridine derivatives useful as aminocarboxymuconate semialdehyde decarboxylase (ACMSD) inhibitors ORSOBIO, INC. (US) 2023-10-10 — — US disclosed
US-11780812-B2 Oxopyridine derivatives useful as aminocarboxymuconate semialdehyde decarboxylase (ACMSD) inhibitors ORSOBIO, INC. (US) 2023-10-10 — — US disclosed
CN-108137513-B Pyrimidine derivatives ASKA 制药株式会社 2022-03-01 — — CN disclosed
EP-3372589-B1 PYRIMIDINE DERIVATIVE ASKA PHARM CO LTD (JP) 2021-10-20 — — EP disclosed
US-20210094916-A1 OXOPYRIDINE DERIVATIVES USEFUL AS AMINOCARBOXYMUCONATE SEMIALDEHYDE DECARBOXYLASE (ACMSD) INHIBITORS ORSOBIO, INC. 2021-04-01 — — US disclosed
US-5547967-A HYPOTENSIVE AGENT, ANTIISCHEMIC AGENT KALI-CHEMIE PHARMA GMBH (DE) 1996-08-20 — — US disclosed
US-4711898-A 4-quinolone derivatives having anti-inflammatory, anti-allergic, antitussive, expectorant and antithrombotic activity NIPPON SHINYAKU CO., LTD. (JP) 1987-12-08 — — US disclosed
EP-0104959-B1 4-QUINOLONE DERIVATIVES NIPPON SHINYAKU COMPANY, LIMITED (JP) 1987-01-21 — — EP disclosed
EP-0104959-A1 4-Quinolone derivatives NIPPON SHINYAKU COMPANY, LIMITED (JP) 1984-04-04 — — EP disclosed
US-4288438-A Nitrogen-containing heterocyclic ring derivatives and analgesic and anti-inflammatory compositions and methods employing them YAMANOUCHI PHARMACEUTICAL CO., LTD. (JP) 1981-09-08 — — US disclosed
US-4284778-A ANALGESICS, ANTIINFLAMMATORY AGENTS YAMANOUCHI PHARMACEUTICAL CO., LTD. (JP) 1981-08-18 — — US disclosed
US-4251533-A ANALGESICS, ANTIINFLAMMATORY AGENTS YAMANOUCHI PHARMACEUTICAL CO., LTD. (JP) 1981-02-17 — — US disclosed
US-4186200-A ANALGESICS, ANTIINFLAMMATORY AGENTS YAMANOUCHI PHARMACEUTICAL CO., LTD. (JP) 1980-01-29 — — US disclosed
US-4020073-A Process for O-acylating thallus salts of 2-pyridone TAYLOR EDWARD C 1977-04-26 — — US disclosed
US-3947488-A O-Acylation using organothallium compounds TAYLOR EDWARD C 1976-03-30 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-12378200-B2 Oxopyridine derivatives useful as aminocarboxymuconate semialdehyde decarboxylase (ACMSD) inhibitors ALDH7A1, ACMSD, AMD1 KMT2A 1309/4885MEN1 1478/4885NPC1 2098/4885
US-20250145572-A1 Aminocarboxymuconate Semialdehyde Decarboxylase (ACMSD) Inhibitors ACMSD, ALDH7A1, ALAD KMT2A 978/4885MEN1 1560/4885NPC1 2371/4885
US-20240059657-A1 OXOPYRIDINE DERIVATIVES USEFUL AS AMINOCARBOXYMUCONATE SEMIALDEHYDE DECARBOXYLASE (ACMSD) INHIBITORS ALDH7A1, ACMSD, AMD1 KMT2A 1309/4885MEN1 1478/4885NPC1 2098/4885
US-20210094916-A1 OXOPYRIDINE DERIVATIVES USEFUL AS AMINOCARBOXYMUCONATE SEMIALDEHYDE DECARBOXYLASE (ACMSD) INHIBITORS ALDH7A1, OTC, DDC KMT2A 1374/4885MEN1 1839/4885NPC1 1962/4885
US-11780812-B2 Oxopyridine derivatives useful as aminocarboxymuconate semialdehyde decarboxylase (ACMSD) inhibitors ALDH7A1, ACMSD, AMD1 KMT2A 1309/4885MEN1 1478/4885NPC1 2098/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.