Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 5/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.56 |
| ▸ | MAPT | P10636 | 6/20 | 0.56 |
| ▸ | NPC1 | O15118 | 3/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.56 |
| ▸ | PYGL | P06737 | 1/20 | 0.55 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.54 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.54 |
| ▸ | PDK3 | Q15120 | 1/20 | 0.54 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.54 |
| ▸ | USP2 | O75604 | 1/20 | 0.54 |
| ▸ | HPGD | P15428 | 1/20 | 0.54 |
| ▸ | HTT | P42858 | 2/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.54 |
| ▸ | POLB | P06746 | 1/20 | 0.54 |
| ▸ | MEN1 | O00255 | 1/20 | 0.54 |
| ▸ | ATM | Q13315 | 2/20 | 0.54 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.54 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5471126 | 0.88 | RAB9A (0.65) | RAB9AALDH1A1MAPTNPC1SMN1; SMN2 | |
| SCHEMBL13453209 | 0.85 | MEN1 (0.62) | RAB9AALDH1A1MAPTSMN1; SMN2PYGL | |
| SCHEMBL11416927 | 0.84 | MAPK1 (0.58) | RAB9AALDH1A1MAPTNPC1SMN1; SMN2 | |
| SCHEMBL11430210 | 0.84 | GAA (0.60) | RAB9AALDH1A1MAPTNPC1SMN1; SMN2 | |
| SCHEMBL6765299 | 0.83 | RAB9A (0.59) | RAB9AALDH1A1MAPTNPC1SMN1; SMN2 | |
| SCHEMBL8473685 | 0.82 | PYGL (0.53) | ALDH1A1SMN1; SMN2PYGLKMT2APOLB | |
| SCHEMBL11420542 | 0.82 | ALDH1A1 (0.48) | RAB9AALDH1A1MAPTNPC1SMN1; SMN2 | |
| SCHEMBL11422548 | 0.82 | SMN1; SMN2 (0.57) | RAB9AALDH1A1MAPTNPC1SMN1; SMN2 | |
| SCHEMBL30930866 | 0.82 | MAPK1 (0.69) | RAB9AALDH1A1MAPTNPC1SMN1; SMN2 | |
| SCHEMBL11435364 | 0.82 | KMT2A (0.58) | RAB9AALDH1A1MAPTNPC1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 18 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7098217-B2 | 3,7-dihydro-purine-2,6-dione derivatives as CRF receptor ligands | BRISTOL-MYERS SQUIBB COMPANY (US) | 2006-08-29 | — | — | US | disclosed |
| US-6894045-B2 | Tetrahydropurinones and derivatives thereof as corticotropin releasing factor receptor ligands | BRISTOL-MYERS SQUIBB PHARMA COMPANY (US) | 2005-05-17 | — | — | US | disclosed |
| US-20050026937-A1 | 3,7-dihydro-purine-2,6-dione derivatives as CRF receptor ligands | BRISTOL-MYERS SQUIBB PHARMA COMPANY | 2005-02-03 | — | — | US | disclosed |
| US-20030149059-A1 | Tetrahydropurinones and derivatives thereof as corticotropin releasing factor receptor ligands | BRISTOL-MYERS SQUIBB PHARMA COMPANY | 2003-08-07 | — | — | US | disclosed |
| US-20030119831-A1 | 3,7-dihydro-purine-2,6-dione derivatives as CRF receptor ligands | BRISTOL-MYERS SQUIBB PHARMA COMPANY | 2003-06-26 | — | — | US | disclosed |
| WO-2003043637-A1 | 3,7-DIHYDRO-PURINE-2,6-DIONE DERIVATIVES AS CRF RECEPTOR LIGANDS | BRISTOL-MYERS SQUIBB PHARMA COMPANY (US) | 2003-05-30 | — | — | WO | disclosed |
| WO-2003005969-A2 | TETRAHYDROPURINONES AS CORTICOTROPIN RELEASING FACTOR | BRISTOL-MYERS SQUIBB PHARMA COMPANY (US) | 2003-01-23 | — | — | WO | disclosed |
| US-5872253-A | MULTISTAGE PROCESS WITH REACTION OF ISOTHIOCYANATE WITH AMINE AND CYCLIZATION THE THIOUREA WITH HALOCARBONYL HALIDE | AMERICAN CYANAMID COMPANY (US) | 1999-02-16 | — | — | US | disclosed |
| US-5726126-A | 1-(3-heterocyclyphenyl)-S-triazine-2,6,6-oxo or thiotrione herbicidal agents | AMERICAN CYANAMID COMPANY (US) | 1998-03-10 | — | — | US | disclosed |
| US-5705644-A | 1-(3-heterocyclphenyl)-s-triazine-2,4,6-oxo or thiotrione herbicidal agents | AMERICAN CYANAMID COMPANY (US) | 1998-01-06 | — | — | US | disclosed |
| US-5679791-A | FROM A CORRESPONDING ISOTHIOCYANATE COMPOUNDS AND A HYDRAZINE COMPOUND | AMERICAN CYANAMID COMPANY (US) | 1997-10-21 | — | — | US | disclosed |
| US-5659031-A | CONTROLLING WEEDS IN CROPS | AMERICAN CYANAMID COMPANY (US) | 1997-08-19 | — | — | US | disclosed |
| US-5616706-A | PREEMERGENCE OR POSTEMERGENCE | AMERICAN CYANAMID COMPANY (US) | 1997-04-01 | — | — | US | disclosed |
| US-5612481-A | 1-(3-heterocyclylphenyl)-s-triazine-2,4,6-oxo or thiortione herbicidal agents | AMERICAN CYANAMID COMPANY (US) | 1997-03-18 | — | — | US | disclosed |
| US-5610120-A | APPLYING COMPOUND TO FOLIAGE OF UNDESIRABLE PLANTS OR TO THE SOIL OR WATER CONTAINING SEEDS THEREOF | AMERICAN CYANAMID COMPANY (US) | 1997-03-11 | — | — | US | disclosed |
| CN-1138580-A | 1-(3-heterocyclylphenyl)-S-triazine-2,4,6-oxo or thiotrione herbicidal agents | AMERICAN CYANAMID CO (US) | 1996-12-25 | — | — | CN | disclosed |
| EP-0745599-A2 | 1-(3-Heterocyclylphenyl)-s-triazine-2,4,6-oxo or thiotrione herbicidal agents | American Cyanamid Company (US) | 1996-12-04 | — | — | EP | disclosed |
| US-4183956-A | Method for treating gastrointestinal spasms, gastrointestinal hyperacidity and hypertensive disorders with amidinoureas | WILLIAM H. RORER, INC. (US) | 1980-01-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030149059-A1 | Tetrahydropurinones and derivatives thereof as corticotropin releasing factor receptor ligands | CRH, CRHR1, CRHR2 | RAB9A 1282/4885ALDH1A1 1044/4885MAPT 659/4885 |
| US-20030119831-A1 | 3,7-dihydro-purine-2,6-dione derivatives as CRF receptor ligands | GPR119, CRHR1, CRH | RAB9A 1915/4885ALDH1A1 1073/4885MAPT 1402/4885 |
| US-20050026937-A1 | 3,7-dihydro-purine-2,6-dione derivatives as CRF receptor ligands | GPR119, CRHR1, CRH | RAB9A 1739/4885ALDH1A1 1062/4885MAPT 1620/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.