Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.39 |
| ▸ | TSHR | P16473 | 2/20 | 0.39 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.39 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.39 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.39 |
| ▸ | HTR2B | P41595 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.38 |
| ▸ | TGM2 | P21980 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 3/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.35 |
| ▸ | LIG1 | P18858 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL942986 | 0.78 | ALDH1A1 (0.43) | HSD17B10ALDH1A1L3MBTL1TDP1ALOX15 | |
| SCHEMBL11318079 | 0.75 | TSHR (0.34) | HSD17B10ALDH1A1L3MBTL1TDP1ALOX15 | |
| SCHEMBL9090785 | 0.75 | TSHR (0.34) | HSD17B10ALDH1A1L3MBTL1TDP1ALOX15 | |
| SCHEMBL27497360 | 0.75 | CYP1B1 (0.40) | ALDH1A1TSHRMAPK1MAPTMEN1 | |
| SCHEMBL28187507 | 0.74 | HTT (0.38) | HSD17B10ALDH1A1L3MBTL1TDP1ALOX15 | |
| SCHEMBL716309 | 0.72 | ALDH1A1 (0.54) | HSD17B10ALDH1A1L3MBTL1TDP1ALOX15 | |
| SCHEMBL11311334 | 0.71 | TGM2 (0.32) | ALDH1A1TSHRCYP3A4CYP1A2TGM2 | |
| SCHEMBL10433957 | 0.71 | RAPGEF4 (0.39) | HSD17B10ALDH1A1L3MBTL1TSHRPTGS2 | |
| SCHEMBL7110909 | 0.71 | SMN1; SMN2 (0.47) | ALDH1A1L3MBTL1TDP1ALOX15TSHR | |
| SCHEMBL4945888 | 0.71 | CYP1A2 (0.40) | ALDH1A1CYP1A2TGM2MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 50 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20060128734-A1 | Diaryl urea derivatives useful for the treatment of protein kinase dependent diseases | FLOERSHEIMER ANDREAS | 2006-06-15 | — | — | US | claimed |
| EP-0287478-B1 | PROCESS FOR PREPARING AROMATIC DIAMINES CONTAINING POLYDIORGANOSILOXANE GROUPS | RHONE-POULENC CHIMIE (FR) | 1992-05-13 | — | — | EP | claimed |
| US-4948858-A | Preparation of diorganopolysiloxylated diamines | RHONE-POULENC CHIMIE (FR) | 1990-08-14 | — | — | US | claimed |
| EP-0287478-A1 | Process for preparing aromatic diamines containing polydiorganosiloxane groups | RHONE-POULENC CHIMIE (FR) | 1988-10-19 | — | — | EP | claimed |
| EP-0271170-A2 | Herbicidal substituted benzofurans and benzopyrans | SHELL INTERNATIONALE RESEARCHMAATSCHAPPIJ B.V. (NL) | 1988-06-15 | — | — | EP | claimed |
| CN-111511750-B | Macrocyclic derivatives, process for their preparation and pharmaceutical compositions containing them | 法国施维雅药厂 | 2023-06-13 | — | — | CN | disclosed |
| US-20220387602-A1 | BIFUNCTIONAL DEGRADERS AND THEIR METHODS OF USE | NOVARTIS AG (CH) | 2022-12-08 | — | — | US | disclosed |
| CN-114940692-A | Compound with anti-lung cancer effect and preparation method and application thereof | 重庆文理学院 | 2022-08-26 | — | — | CN | disclosed |
| EP-4031247-A1 | BIFUNCTIONAL DEGRADERS AND THEIR METHODS OF USE | Novartis AG (CH) | 2022-07-27 | — | — | EP | disclosed |
| CN-114521196-A | Bifunctional group degradation agent and use method thereof | 诺华股份有限公司 | 2022-05-20 | — | — | CN | disclosed |
| EP-2945702-A1 | HYDROXY ALIPHATIC SUBSTITUTED PHENYL AMINOALKYL ETHER DERIVATIVES | Prous Institute for Biomedical Research, S.A. (ES) | 2015-11-25 | — | — | EP | disclosed |
| WO-2014096377-A1 | HYDROXY ALIPHATIC SUBSTITUTED PHENYL AMINOALKYL ETHER DERIVATIVES | PROUS INSTITUTE FOR BIOMEDICAL RESEARCH, S.A. (ES) | 2014-06-26 | — | — | WO | disclosed |
| EP-0287478-A1 | Process for preparing aromatic diamines containing polydiorganosiloxane groups | RHONE-POULENC CHIMIE (FR) | 1988-10-19 | — | — | EP | disclosed |
| US-4777237-A | HEAT-RESISTANT THERMOSETTING MOLDING MATERIALS | RHONE-POULENC SPECIALITIES CHIMIQUES (FR) | 1988-10-11 | — | — | US | disclosed |
| EP-0284519-A1 | Bismaleimide siloxanes and process for their preparation | CIBA-GEIGY AG (CH) | 1988-09-28 | — | — | EP | disclosed |
| EP-0284520-A1 | Thermally stable polymers based on maleimides, among which a bis-maleimide-siloxane, and processes for their preparation | RHONE-POULENC CHIMIE (FR) | 1988-09-28 | — | — | EP | disclosed |
| EP-0284524-A1 | Thermostable polymers based on maleimides, of which one is a bismaleimide-siloxane, and on aromatic diamines, and process for their preparation | RHONE-POULENC CHIMIE (FR) | 1988-09-28 | — | — | EP | disclosed |
| EP-0271170-A2 | Herbicidal substituted benzofurans and benzopyrans | SHELL INTERNATIONALE RESEARCHMAATSCHAPPIJ B.V. (NL) | 1988-06-15 | — | — | EP | disclosed |
| US-4742141-A | HEAT-STABLE; IMPREGNANTS; COATING OR MOLDING RESINS | RHONE-POULENC SPECIALITES CHIMIQUES (FR) | 1988-05-03 | — | — | US | disclosed |
| US-4128561-A | Process for the preparation of 2-(2-thienyl)-ethylamine and derivatives thereof | PARCOR (FR) | 1978-12-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220387602-A1 | BIFUNCTIONAL DEGRADERS AND THEIR METHODS OF USE | JMJD7, MDM2, IDE | HSD17B10 1399/4885ALDH1A1 2189/4885L3MBTL1 1534/4885 |
| US-20060128734-A1 | Diaryl urea derivatives useful for the treatment of protein kinase dependent diseases | UCK2, PRKDC, PRKACA | HSD17B10 3272/4885ALDH1A1 3040/4885L3MBTL1 2936/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.