Citric Acid

Citric Acid

SCHEMBL5874339

CNC.CNC.CNC.O=C(O)CC(O)(CC(=O)O)C(=O)O

nearest known ligand 0.79

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

ACVR1ADORA1ADORA2AADORA2BADORA3ESR1ESR2FLT3GRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BGSC1HRH1HTR7IDH1IDH2IRAK1JAK1JAK2JAK3MEN1OPRM1P2RX3PDE5ASCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASIGMAR1SLC6A2SYKTACR1TOP2ATYK2

The experimentally established mechanism targets of Citric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
MEN1 known ✓ O00255 1/20 0.41
ALDH1A1 P00352 3/20 0.79
HMGCR P04035 1/20 0.48
CHRM1 P11229 1/20 0.48
TBXA2R P21731 1/20 0.48
ADRA1A P35348 1/20 0.48
TSHR P16473 3/20 0.46
CYP2D6 P10635 2/20 0.46
CYP2C19 P33261 1/20 0.46
HIF1A Q16665 1/20 0.46
KDM4E B2RXH2 3/20 0.43
LMNA P02545 3/20 0.43
MAPT P10636 1/20 0.43
ALOX15 P16050 1/20 0.43
SLC13A5 Q86YT5 4/20 0.42
CYP1A2 P05177 1/20 0.41
KMT2A Q03164 1/20 0.41
ACLY P53396 3/20 0.39
CPT2 P23786 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Citric Acid SCHEMBL3454616 1.00 ALDH1A1 (0.79) ALDH1A1HMGCRCHRM1TBXA2RADRA1A
Citric Acid SCHEMBL7791059 0.97 ALDH1A1 (0.75) ALDH1A1HMGCRCHRM1TBXA2RADRA1A
Citric Acid SCHEMBL28291026 0.90 ALDH1A1 (0.71) ALDH1A1HMGCRCHRM1TBXA2RADRA1A
Citric Acid SCHEMBL30359537 0.89 ALDH1A1 (0.88) ALDH1A1HMGCRCHRM1TBXA2RADRA1A
Citric Acid SCHEMBL2396390 0.89 ALDH1A1 (0.88) ALDH1A1HMGCRCHRM1TBXA2RADRA1A
Citric Acid SCHEMBL3417188 0.89 ALDH1A1 (1.00) ALDH1A1HMGCRCHRM1TBXA2RADRA1A
Citric Acid SCHEMBL10896997 0.89 ALDH1A1 (1.00) ALDH1A1HMGCRCHRM1TBXA2RADRA1A
Citric Acid SCHEMBL240402 0.89 ALDH1A1 (1.00) ALDH1A1HMGCRCHRM1TBXA2RADRA1A
Citric Acid SCHEMBL842 0.89 ALDH1A1 (1.00) ALDH1A1HMGCRCHRM1TBXA2RADRA1A
Citric Acid SCHEMBL725546 0.89 ALDH1A1 (1.00) ALDH1A1HMGCRCHRM1TBXA2RADRA1A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2017046709-A1 BIOCIDES AND PREPARATION THEREOF BIOLOGICAL CHEMICAL TECHNOLOGIES (PTY) LTD T/A BIODX (ZA) 2017-03-23 WO claimed
US-12629387-B2 Composition of antiviral agent for use in prophylactic or post-exposure treatment of infectious or respiratory diseases INSPIRMED CORP. (TW) 2026-05-19 US disclosed
US-20230181615-A1 COMPOSITION OF ANTIVIRAL AGENT FOR USE IN PROPHYLACTIC OR POST-EXPOSURE TREATMENT OF INFECTIOUS OR RESPIRATORY DISEASES INSPIRMED CORP (TW) 2023-06-15 US disclosed
EP-4125810-A1 COMPOSITION OF ANTIVIRAL AGENT FOR USE IN PROPHYLACTIC OR POST-EXPOSURE TREATMENT OF INFECTIOUS OR RESPIRATORY DISEASES InspirMed Corp. (TW) 2023-02-08 EP disclosed
CN-115315252-A Antiviral composition for preventing or treating infection or respiratory disease after exposure 盈擘医药股份有限公司 2022-11-08 CN disclosed
US-20220211623-A1 INHALABLE SUSTAINED RELEASE COMPOSITION OF BRONCHODILATOR FOR USE IN TREATING PULMONARY DISEASE INSPIRMED CORP. (TW) 2022-07-07 US disclosed
EP-3968951-A1 INHALABLE SUSTAINED RELEASE COMPOSITION OF BRONCHODILATOR FOR USE IN TREATING PULMONARY DISEASE Inspirmed Corp (TW) 2022-03-23 EP disclosed
WO-2021194927-A1 COMPOSITION OF ANTIVIRAL AGENT FOR USE IN PROPHYLACTIC OR POST-EXPOSURE TREATMENT OF INFECTIOUS OR RESPIRATORY DISEASES TLC BIOPHARMACEUTICALS, INC. (US) 2021-09-30 WO disclosed
WO-2020232198-A1 INHALABLE SUSTAINED RELEASE COMPOSITION OF BRONCHODILATOR FOR USE IN TREATING PULMONARY DISEASE TLC BIOPARMACEUTICALS, INC. (US) 2020-11-19 WO disclosed
US-20200179254-A1 IMPROVED CONDITIONING HAIR TREATMENT PRODUCT WITH WASHOUT PROTECTION HENKEL AG & CO. KGAA (DE) 2020-06-11 US disclosed
US-20190240129-A1 CONDITIONING HAIR TREATMENT PRODUCT WITH WASHOUT PROTECTION HENKEL AG & CO. KGAA (DE) 2019-08-08 US disclosed
EP-3518878-A1 IMPROVED CONDITIONING HAIR TREATMENT PRODUCT WITH WASHOUT PROTECTION Henkel AG & Co. KGaA (DE) 2019-08-07 EP disclosed
US-20190216714-A1 IMPROVED CONDITIONING HAIR TREATMENT PRODUCT WITH WASHOUT PROTECTION HENKEL AG & CO. KGAA (DE) 2019-07-18 US disclosed
US-20190216703-A1 IMPROVED CONDITIONING HAIR TREATMENT PRODUCT WITH WASHOUT PROTECTION HENKEL AG & CO. KGAA (DE) 2019-07-18 US disclosed
WO-2017046709-A1 BIOCIDES AND PREPARATION THEREOF BIOLOGICAL CHEMICAL TECHNOLOGIES (PTY) LTD T/A BIODX (ZA) 2017-03-23 WO disclosed
US-7128976-B2 Composition for film formation, method of film formation, and silica-based film JSR CORPORATION (JP) 2006-10-31 US disclosed
US-20030091838-A1 Composition for film formation, method of film formation, and silica-based film JSR CORPORATION (JP) 2003-05-15 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20190240129-A1 CONDITIONING HAIR TREATMENT PRODUCT WITH WASHOUT PROTECTION KRT18, CUTA, S100A10 MEN1 3369/4885ALDH1A1 1010/4885HMGCR 3426/4885
US-12629387-B2 Composition of antiviral agent for use in prophylactic or post-exposure treatment of infectious or respiratory diseases IFNAR1, NPC1, SGMS1 MEN1 3475/4885ALDH1A1 4342/4885HMGCR 66/4885
US-20190216703-A1 IMPROVED CONDITIONING HAIR TREATMENT PRODUCT WITH WASHOUT PROTECTION KRT18, SRRM2, IK MEN1 4505/4885ALDH1A1 3629/4885HMGCR 2361/4885
US-20230181615-A1 COMPOSITION OF ANTIVIRAL AGENT FOR USE IN PROPHYLACTIC OR POST-EXPOSURE TREATMENT OF INFECTIOUS OR RESPIRATORY DISEASES LIPA, MAVS, ISG15 MEN1 2858/4885ALDH1A1 3863/4885HMGCR 1863/4885
US-20190216714-A1 IMPROVED CONDITIONING HAIR TREATMENT PRODUCT WITH WASHOUT PROTECTION KRT18, CD44, PCNA MEN1 2001/4885ALDH1A1 1465/4885HMGCR 4250/4885
US-20200179254-A1 IMPROVED CONDITIONING HAIR TREATMENT PRODUCT WITH WASHOUT PROTECTION KRT18, CUTA, DSG1 MEN1 3038/4885ALDH1A1 1179/4885HMGCR 3266/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.