Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALKBH1 | Q13686 | 5/20 | 0.51 |
| ▸ | P4HTM | Q9NXG6 | 1/20 | 0.46 |
| ▸ | PKM | P14618 | 1/20 | 0.44 |
| ▸ | NR4A3 | Q92570 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | PTGER1 | P34995 | 1/20 | 0.43 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.43 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.43 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.43 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.43 |
| ▸ | FOLH1 | Q04609 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | PLA2G4B | P0C869 | 1/20 | 0.41 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.41 |
| ▸ | MAOB | P27338 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17012297 | 0.86 | PRMT5 (0.42) | ALKBH1P4HTMPKMALDH1A1PRMT5 | |
| SCHEMBL4701633 | 0.85 | HPGD (0.50) | ALDH1A1MEN1KMT2ATSHR | |
| SCHEMBL14973158 | 0.84 | MAOB (0.46) | PTGER1MAOB | |
| SCHEMBL19918850 | 0.83 | MAPT (0.44) | NR4A3ALDH1A1MEN1KMT2APLA2G4B | |
| SCHEMBL10961245 | 0.81 | ALKBH1 (0.41) | ALKBH1PKMALDH1A1PRMT5WDR77 | |
| SCHEMBL13766725 | 0.79 | CNR1 (0.47) | PKM | |
| SCHEMBL148140 | 0.79 | NPC1 (0.48) | ALKBH1ALDH1A1PTGER1MEN1KMT2A | |
| SCHEMBL1758500 | 0.77 | MAPK14 (0.44) | ALKBH1P4HTMPKMALDH1A1FOLH1 | |
| SCHEMBL23087256 | 0.77 | PRMT5 (0.45) | PKMALDH1A1PRMT5WDR77CYP1A2 | |
| SCHEMBL31002249 | 0.77 | PKM (0.44) | PKMALDH1A1PRMT5WDR77CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 22 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1486489-B1 | Fungicidal heterocyclic aromatic amides and their compositions, methods of use and preparation | DOW AGROSCIENCES LLC (US) | 2016-04-27 | — | — | EP | disclosed |
| EP-1953145-B1 | HETEROCYCLIC COMPOUND HAVING INHIBITORY ACTIVITY ON 11-B-HYDROXYSTEROID DEHYDROGENASE TYPE I | SHIONOGI & CO (JP) | 2015-11-04 | — | — | EP | disclosed |
| US-8324265-B2 | Heterocyclic compounds having type I 11β hydroxysteroid dehydrogenase inhibitory activity | SHIONOGI & CO., LTD. (JP) | 2012-12-04 | — | — | US | disclosed |
| US-8324265-B2 | Heterocyclic compounds having type I 11β hydroxysteroid dehydrogenase inhibitory activity | SHIONOGI & CO., LTD. (JP) | 2012-12-04 | — | — | US | disclosed |
| US-20090170832-A1 | HETEROCYCLIC COMPOUNDS HAVING TYPE I 11beta HYDROXYSTEROID DEHYDROGENASE INHIBITORY ACTIVITY | SHIONOGI & CO., LTD. (JP) | 2009-07-02 | — | — | US | disclosed |
| US-20090170832-A1 | HETEROCYCLIC COMPOUNDS HAVING TYPE I 11beta HYDROXYSTEROID DEHYDROGENASE INHIBITORY ACTIVITY | SHIONOGI & CO., LTD. (JP) | 2009-07-02 | — | — | US | disclosed |
| EP-1953145-A1 | HETEROCYCLIC COMPOUND HAVING INHIBITORY ACTIVITY ON 11- -HYDROXYSTEROID DEHYDROGENASE TYPE I | Shionogi & Co., Ltd. (JP) | 2008-08-06 | — | — | EP | disclosed |
| EP-1204643-B1 | FUNGICIDAL HETEROCYCLIC AROMATIC AMIDES AND THEIR COMPOSITIONS, METHODS OF USE AND PREPARATION | DOW AGROSCIENCES LLC (US) | 2008-06-04 | — | — | EP | disclosed |
| US-RE39991-E1 | Fungicidal heterocyclic aromatic amides and their compositions, methods of use and preparation | DOW AGROSCIENCES LLC (US) | 2008-01-01 | — | — | US | disclosed |
| US-7034035-B2 | Fungicidal mono-, bi-, and tri-cycloheteroalkyl amides and their compositions, methods of use and preparation | DOW AGROSCIENCES LLC (US) | 2006-04-25 | — | — | US | disclosed |
| CN-1208321-C | Fungicidal heterocyclic aromatic amides and their compositions methods of use and preparation | DOW AGROSCIENCES LLC (US) | 2005-06-29 | — | — | CN | disclosed |
| US-20040034025-A1 | Fungicidal heterocyclic aromatic amides and their compositions, methods of use and preparation | RICKS MICHAEL J (US) | 2004-02-19 | — | — | US | disclosed |
| CN-1450993-A | Fungicidal heterocyclic aromatic amides and their compositions, methods of use and preparation | DOW AGROSCIENCES LLC (US) | 2003-10-22 | — | — | CN | disclosed |
| US-6521622-B1 | Effective against plant pathogens and wood decaying fungi | DOW AGROSCIENCES LLC | 2003-02-18 | — | — | US | disclosed |
| US-20030022903-A1 | Fungicidal heterocyclic aromatic amides and their compositions, methods of use and preparation | RICKS MICHAEL J (US) | 2003-01-30 | — | — | US | disclosed |
| US-20030022902-A1 | Fungicidal heterocyclic aromatic amides and their compositions, methods of use and preparation | RICKS MICHAEL J (US) | 2003-01-30 | — | — | US | disclosed |
| US-20030018012-A1 | Fungicidal heterocyclic aromatic amides and their compositions, methods of use and preparation | RICKS MICHAEL J (US) | 2003-01-23 | — | — | US | disclosed |
| US-20030018052-A1 | Fungicidal heterocyclic aromatic amides and their compositions, methods of use and preparation | RICKS MICHAEL J (US) | 2003-01-23 | — | — | US | disclosed |
| CN-1390204-A | Fungicidal heterocyclic aromatic amides and their compositions, methods of use and preparation | DOW AGRO SCIENCES LLC (US) | 2003-01-08 | — | — | CN | disclosed |
| US-20020177578-A1 | Fungicidal heterocyclic aromatic amides and their compositions, methods of use and preparation | RICKS MICHAEL J (US) | 2002-11-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030018012-A1 | Fungicidal heterocyclic aromatic amides and their compositions, methods of use and preparation | CYP4X1, CYP1A1, NAT1 | ALKBH1 960/4885P4HTM 397/4885PKM 1676/4885 |
| US-20020177578-A1 | Fungicidal heterocyclic aromatic amides and their compositions, methods of use and preparation | CYP4X1, CYP1A1, NAT1 | ALKBH1 960/4885P4HTM 397/4885PKM 1676/4885 |
| US-20040034025-A1 | Fungicidal heterocyclic aromatic amides and their compositions, methods of use and preparation | AADAC, NAT1, AHR | ALKBH1 329/4885P4HTM 448/4885PKM 3282/4885 |
| US-20030022903-A1 | Fungicidal heterocyclic aromatic amides and their compositions, methods of use and preparation | CYP4X1, NAT1, CYP1A1 | ALKBH1 827/4885P4HTM 433/4885PKM 1782/4885 |
| US-20090170832-A1 | HETEROCYCLIC COMPOUNDS HAVING TYPE I 11beta HYDROXYSTEROID DEHYDROGENASE INHIBITORY ACTIVITY | HSD17B1, HSD11B1, HSD3B1 | ALKBH1 2102/4885P4HTM 981/4885PKM 4451/4885 |
| US-20030018052-A1 | Fungicidal heterocyclic aromatic amides and their compositions, methods of use and preparation | NAT1, CYP4X1, CYP1A1 | ALKBH1 777/4885P4HTM 404/4885PKM 1573/4885 |
| US-20030022902-A1 | Fungicidal heterocyclic aromatic amides and their compositions, methods of use and preparation | NAT1, CYP1A1, CYP4X1 | ALKBH1 787/4885P4HTM 423/4885PKM 1797/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.