SCHEMBL5884665

SCHEMBL5884665

CON=Cc1ccc(OCCC2CCN(c3ccc(C)nn3)CC2)cc1C

nearest known ligand 0.38

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
PPARG P37231 4/20 0.38
PPARD Q03181 4/20 0.38
OGA O60502 1/20 0.35
OPRK1 P41145 2/20 0.35
GPR119 Q8TDV5 2/20 0.34
HPGD P15428 1/20 0.34
ENPP1 P22413 2/20 0.34
NR1I2 O75469 1/20 0.34
PPARA Q07869 3/20 0.33
SSTR2 P30874 1/20 0.32
CHEK2 O96017 1/20 0.31
CHRM4 P08173 1/20 0.31
ACACB O00763 1/20 0.31
PDE2A O00408 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5884543 0.91 OPRK1 (0.38) PPARGPPARDOGAOPRK1GPR119
SCHEMBL5884663 0.88 GPR119 (0.35) PPARGPPARDOGAOPRK1GPR119
SCHEMBL5884479 0.86 CTSS (0.35) PPARGPPARDOGAOPRK1HPGD
SCHEMBL5884362 0.86 NR1I2 (0.38) GPR119HPGDNR1I2ACACB
SCHEMBL5884326 0.85 NPC1 (0.38) PPARGPPARDGPR119PPARA
SCHEMBL5884402 0.83 OPRK1 (0.33) PPARGPPARDOGAOPRK1NR1I2
SCHEMBL5884608 0.83 HPGD (0.40) PPARGPPARDOGAOPRK1GPR119
SCHEMBL5884356 0.81 HRH3 (0.38) GPR119HPGDNR1I2
SCHEMBL5884729 0.80 NPC1 (0.37)
SCHEMBL14499355 0.79 PPARG (0.39) PPARGPPARDOGAGPR119HPGD

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7078403-B1 Antiviral agents BIOTA SCIENTIFIC MANAGEMENT PTY LTD. (AU) 2006-07-18 US claimed