Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR2 | Q92731 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | PGR | P06401 | 2/20 | 0.36 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.36 |
| ▸ | TAAR1 | Q96RJ0 | 2/20 | 0.35 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.33 |
| ▸ | PARP11 | Q9NR21 | 1/20 | 0.33 |
| ▸ | TDP2 | O95551 | 1/20 | 0.33 |
| ▸ | GRM5 | P41594 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5887404 | 0.90 | L3MBTL1 (0.40) | ESR2PGRPARP10PARP11 | |
| SCHEMBL5887582 | 0.80 | TSHR (0.43) | PGRTDP2 | |
| SCHEMBL6047653 | 0.79 | HSD11B1 (0.37) | — | |
| SCHEMBL4808757 | 0.75 | ESR2 (0.39) | ESR2SMN1; SMN2PGRALOX5TAAR1 | |
| SCHEMBL5887443 | 0.75 | ACHE (0.46) | SMN1; SMN2ALOX5 | |
| SCHEMBL6047589 | 0.74 | PTGS1 (0.35) | SMN1; SMN2PGR | |
| SCHEMBL3793227 | 0.73 | ESR2 (0.60) | ESR2SMN1; SMN2PGRALOX5TAAR1 | |
| SCHEMBL5887382 | 0.71 | L3MBTL1 (0.35) | SMN1; SMN2PGRPARP10PARP11 | |
| SCHEMBL4012821 | 0.67 | ESR2 (0.36) | ESR2SMN1; SMN2ALOX5 | |
| SCHEMBL5887105 | 0.66 | ESR2 (0.35) | ESR2SMN1; SMN2ALOX5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7037931-B2 | Corticotropin releasing factor moderator; analgesics; drug abruse, drug dependency; schizophrenia | JANSSEN PHARMACEUTICA N.V. (BE) | 2006-05-02 | — | — | US | claimed |