SCHEMBL5887582

SCHEMBL5887582

Cc1ccc(C2=C(Cl)C(Cl)=C(c3cccc([N+](=O)[O-])c3)[CH]C2)cc1

nearest known ligand 0.43

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TSHR P16473 1/20 0.43
ACHE P22303 1/20 0.43
MAOB P27338 1/20 0.42
NFE2L2 Q16236 1/20 0.42
MAPT P10636 5/20 0.41
ALDH1A1 P00352 4/20 0.41
GAA P10253 2/20 0.41
NPC1 O15118 1/20 0.41
HPGD P15428 1/20 0.41
CASP3 P42574 1/20 0.41
HTT P42858 1/20 0.41
RAB9A P51151 1/20 0.41
SENP7 Q9BQF6 1/20 0.41
TDP1 Q9NUW8 2/20 0.41
KDM4E B2RXH2 1/20 0.41
MAPK1 P28482 1/20 0.41
MMP2 P08253 1/20 0.40
MMP9 P14780 1/20 0.40
MMP8 P22894 1/20 0.40
MMP13 P45452 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5887404 0.82 L3MBTL1 (0.40) ACHEMAOBMAPTALDH1A1HPGD
SCHEMBL5887672 0.80 ESR2 (0.40) PGRTDP2
SCHEMBL1036939 0.75 TSHR (0.63) TSHRACHEMAOBNFE2L2MAPT
SCHEMBL6047653 0.72 HSD11B1 (0.37) MAPTMMP2
SCHEMBL28770354 0.72 HPRT1 (0.52) TSHRACHEMAOBNFE2L2MAPT
SCHEMBL11524099 0.69 APP (0.59) TSHRACHEMAOBNFE2L2MAPT
SCHEMBL4593078 0.68 ALDH1A1 (0.62) TSHRACHEMAOBNFE2L2MAPT
SCHEMBL6047589 0.68 PTGS1 (0.35) NPC1RAB9APGRMEN1KMT2A
SCHEMBL12360611 0.67 TSHR (0.78) TSHRACHEMAOBNFE2L2MAPT
SCHEMBL847769 0.67 TSHR (0.61) TSHRACHEMAOBNFE2L2MAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7037931-B2 Corticotropin releasing factor moderator; analgesics; drug abruse, drug dependency; schizophrenia JANSSEN PHARMACEUTICA N.V. (BE) 2006-05-02 US claimed
JP-2006501194-A 2006-01-12 JP claimed
EP-1525190-A1 CCK-1 RECEPTOR MODULATORS JANSSEN PHARMACEUTICA N.V. (BE) 2005-04-27 EP claimed
WO-2004007463-A1 CCK-1 RECEPTOR MODULATORS JANSSEN PHARMACEUTICA, N.V. (BE) 2004-01-22 WO claimed