Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR1 | P03372 | 1/20 | 0.55 |
| ▸ | YWHAB | P31946 | 1/20 | 0.55 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.55 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.53 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.53 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.53 |
| ▸ | HDAC10 | Q969S8 | 2/20 | 0.53 |
| ▸ | HDAC11 | Q96DB2 | 2/20 | 0.53 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.53 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.53 |
| ▸ | NCOR2 | Q9Y618 | 2/20 | 0.53 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.53 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.53 |
| ▸ | TAAR1 | Q96RJ0 | 3/20 | 0.52 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.52 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.52 |
| ▸ | CA12 | O43570 | 1/20 | 0.51 |
| ▸ | CA2 | P00918 | 1/20 | 0.51 |
| ▸ | CA9 | Q16790 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6956890 | 0.80 | SPR (0.70) | ESR1YWHABPDK1TAAR1PTPN1 | |
| SCHEMBL9770486 | 0.79 | PTPN1 (0.78) | ESR1YWHABPDK1TAAR1PTPN1 | |
| SCHEMBL17117361 | 0.79 | ESR1 (0.56) | ESR1YWHABPDK1HDAC3HDAC1 | |
| SCHEMBL11359120 | 0.79 | ESR1 (0.56) | ESR1YWHABPDK1HDAC3HDAC1 | |
| SCHEMBL9124718 | 0.77 | ESR1 (0.55) | ESR1YWHABPDK1HDAC3HDAC1 | |
| SCHEMBL27411901 | 0.77 | ALDH1A1 (0.60) | TAAR1SMN1; SMN2ALDH1A1MAPTRECQL | |
| SCHEMBL7765076 | 0.77 | L3MBTL1 (0.79) | HDAC3HDAC1HDAC2HDAC10HDAC11 | |
| SCHEMBL2560739 | 0.77 | MAPT (0.65) | ESR1YWHABPDK1TAAR1PTPN1 | |
| SCHEMBL14308570 | 0.77 | NPC1 (0.55) | HDAC3HDAC1HDAC2HDAC10HDAC11 | |
| SCHEMBL770890 | 0.76 | TAAR1 (0.73) | HDAC3HDAC1HDAC2HDAC10HDAC11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7105545-B2 | N-p-propargyloxyphenethyl-thioacetic acid amides | SYNGENTA CROP PROTECTION, INC. (US) | 2006-09-12 | — | — | US | disclosed |
| US-20040127739-A1 | Novel n-p-propargyloxyphenethyl-thioacetic acid amides | SYNGENTA CROP PROTECTION, INC. | 2004-07-01 | — | — | US | disclosed |
| EP-1373197-A2 | NOVEL N-P-PROPARGYLOXYPHENETHYL-THIOACETIC ACID AMIDES | Syngenta Participations AG (CH) | 2004-01-02 | — | — | EP | disclosed |
| WO-2002081437-A2 | NOVEL N-P-PROPARGYLOXYPHENETHYL-THIOACETIC ACID AMIDES | SYNGENTA PARTICIPATIONS AG (CH) | 2002-10-17 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040127739-A1 | Novel n-p-propargyloxyphenethyl-thioacetic acid amides | O60361, OGA, GRHPR | ESR1 3881/4885YWHAB 1662/4885PDK1 4071/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.