Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FPR2 | P25090 | 1/20 | 0.43 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.43 |
| ▸ | SIRT6 | Q8N6T7 | 2/20 | 0.38 |
| ▸ | CA2 | P00918 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | TMEM97 | Q5BJF2 | 2/20 | 0.35 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.35 |
| ▸ | JAK2 | O60674 | 2/20 | 0.33 |
| ▸ | NTRK1 | P04629 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | PKM | P14618 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | CASP1 | P29466 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27751224 | 0.78 | CA2 (0.47) | FPR2SCN9ASIRT6CA2ALDH1A1 | |
| SCHEMBL28344599 | 0.72 | FPR2 (0.37) | FPR2SCN9ASIRT6CA2ALDH1A1 | |
| SCHEMBL2658028 | 0.72 | SIRT6 (0.40) | FPR2SCN9ASIRT6ADRA1A | |
| SCHEMBL7129931 | 0.68 | CA2 (0.43) | FPR2SCN9ACA2ALDH1A1NPSR1 | |
| SCHEMBL2662008 | 0.68 | TMEM97 (0.45) | FPR2SCN9ACA2ALDH1A1NPSR1 | |
| SCHEMBL1080225 | 0.68 | TMEM97 (0.45) | FPR2SCN9ACA2ALDH1A1NPSR1 | |
| SCHEMBL1760416 | 0.66 | CA2 (0.44) | FPR2SCN9ACA2ALDH1A1NPSR1 | |
| SCHEMBL14881925 | 0.66 | CA2 (0.39) | CA2ALDH1A1NPSR1TMEM97SIGMAR1 | |
| SCHEMBL14881606 | 0.66 | CA2 (0.39) | CA2ALDH1A1NPSR1TMEM97SIGMAR1 | |
| SCHEMBL14881605 | 0.66 | CA2 (0.39) | CA2ALDH1A1NPSR1TMEM97SIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120100078-A1 | Pyrazine Derivatives and Uses Thereof in Renal Monitoring | MALLINCKRODT LLC (US) | 2012-04-26 | — | — | US | disclosed |
| US-8115000-B2 | Pyrazine derivatives and uses thereof in renal monitoring | MALLINCKRODT LLC (US) | 2012-02-14 | — | — | US | disclosed |
| EP-2376459-A1 | MODIFIED PYRAZINE DERIVATIVES AND USES THEREOF | Mallinckrodt LLC (US) | 2011-10-19 | — | — | EP | disclosed |
| US-20110250139-A1 | Modified Pyrazine Derivatives and Uses Thereof | MEDIBEACON, INC. | 2011-10-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110250139-A1 | Modified Pyrazine Derivatives and Uses Thereof | GLS, GLS2, PLPBP | FPR2 439/4885SCN9A 4877/4885SIRT6 2338/4885 |
| US-20120100078-A1 | Pyrazine Derivatives and Uses Thereof in Renal Monitoring | CYP3A5, GLS, XDH | FPR2 112/4885SCN9A 4492/4885SIRT6 1607/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.