Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CD | O00329 | 2/20 | 0.39 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.38 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.38 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.38 |
| ▸ | NAMPT | P43490 | 8/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.36 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.36 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.36 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.36 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.36 |
| ▸ | CKS1B | P61024 | 1/20 | 0.36 |
| ▸ | SKP1 | P63208 | 1/20 | 0.36 |
| ▸ | SKP2 | Q13309 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5895165 | 0.82 | PIK3CD (0.39) | PIK3CDNAMPTNR1H2 | |
| SCHEMBL5895291 | 0.76 | GPR4 (0.37) | HDAC1HDAC8HDAC6ALOX15TSHR | |
| SCHEMBL5895966 | 0.75 | HDAC1 (0.38) | HDAC1HDAC8HDAC6NAMPTALOX15 | |
| SCHEMBL5896071 | 0.73 | ALOX15 (0.36) | HDAC1HDAC8HDAC6NAMPTALOX15 | |
| SCHEMBL5895582 | 0.73 | SPR (0.36) | PIK3CDHDAC1HDAC8HDAC6ALOX15 | |
| SCHEMBL5895808 | 0.72 | GPR4 (0.37) | HDAC1HDAC8HDAC6NAMPTALOX15 | |
| SCHEMBL5895543 | 0.72 | TSHR (0.36) | PIK3CDHDAC1HDAC8HDAC6ALOX15 | |
| SCHEMBL5895541 | 0.72 | TSHR (0.36) | HDAC1HDAC8HDAC6NAMPTALOX15 | |
| SCHEMBL20738562 | 0.72 | NR1H2 (0.43) | PIK3CDHDAC1NAMPTNR1H2 | |
| SCHEMBL3438854 | 0.71 | GPR119 (0.47) | HDAC1HDAC8HDAC6ALOX15TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7091211-B2 | Cyclopentyl modulators of chemokine receptor activity | MERCK & CO., INC. (US) | 2006-08-15 | — | — | US | disclosed |
| US-20050070609-A1 | Cyclopentyl modulators of chemokine receptor activity | MERCK SHARP & DOHME CORP. | 2005-03-31 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050070609-A1 | Cyclopentyl modulators of chemokine receptor activity | CCR5, CXCR1, ACKR3 | PIK3CD 3849/4885HDAC1 1546/4885HDAC8 3173/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.