Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKR1C3 | P42330 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.48 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.48 |
| ▸ | ERCC5 | P28715 | 1/20 | 0.46 |
| ▸ | FEN1 | P39748 | 1/20 | 0.46 |
| ▸ | KAT6A | Q92794 | 1/20 | 0.44 |
| ▸ | TAS2R14 | Q9NYV8 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | RXRA | P19793 | 1/20 | 0.44 |
| ▸ | RXRB | P28702 | 1/20 | 0.44 |
| ▸ | RXRG | P48443 | 1/20 | 0.44 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.43 |
| ▸ | S100A9 | P06702 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.43 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5899559 | 0.89 | ACLY (0.51) | AKR1C3KMT2AKAT6AMEN1ALDH1A1 | |
| SCHEMBL5320468 | 0.85 | MMP1 (0.56) | KMT2AERCC5FEN1MEN1ALDH1A1 | |
| SCHEMBL24590604 | 0.84 | MAPT (0.57) | KMT2AERCC5FEN1TAS2R14MEN1 | |
| SCHEMBL5899484 | 0.84 | ALDH1A1 (0.50) | AKR1C3KMT2AMEN1ALDH1A1HPGD | |
| SCHEMBL5899475 | 0.79 | ALDH1A1 (0.53) | KMT2AMEN1ALDH1A1HPGDSMN1; SMN2 | |
| SCHEMBL16265375 | 0.76 | MEN1 (0.52) | KMT2AMEN1ALDH1A1HPGDSMN1; SMN2 | |
| SCHEMBL30511469 | 0.76 | MAPT (0.66) | KMT2AERCC5FEN1MEN1ALDH1A1 | |
| SCHEMBL16914842 | 0.76 | CA1 (0.61) | KMT2ARXFP1S100A9 | |
| SCHEMBL754846 | 0.76 | ALDH1A1 (0.52) | AKR1C3KMT2AERCC5FEN1KAT6A | |
| SCHEMBL1515772 | 0.76 | MAPT (0.66) | KMT2AERCC5FEN1MEN1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20060025445-A1 | 11-Beta HSD1 inhibitors | WYETH | 2006-02-02 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060025445-A1 | 11-Beta HSD1 inhibitors | HSD11B1, HSD11B2, HSD3B1 | AKR1C3 129/4885KMT2A 1509/4885RXFP1 1812/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.