Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACLY | P53396 | 1/20 | 0.51 |
| ▸ | KAT6A | Q92794 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 5/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.42 |
| ▸ | MEN1 | O00255 | 3/20 | 0.42 |
| ▸ | HPGD | P15428 | 2/20 | 0.42 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | CES1 | P23141 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 2/20 | 0.41 |
| ▸ | RAB9A | P51151 | 2/20 | 0.41 |
| ▸ | USP2 | O75604 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5899423 | 0.89 | AKR1C3 (0.49) | KAT6AKMT2ASMN1; SMN2MEN1HPGD | |
| SCHEMBL5899484 | 0.87 | ALDH1A1 (0.50) | MAPTKMT2ASMN1; SMN2MEN1HPGD | |
| SCHEMBL5320468 | 0.84 | MMP1 (0.56) | MAPTKMT2ASMN1; SMN2MEN1HPGD | |
| SCHEMBL24590604 | 0.84 | MAPT (0.57) | MAPTKMT2AMEN1HPGDALDH1A1 | |
| SCHEMBL754846 | 0.78 | ALDH1A1 (0.52) | KAT6AMAPTKMT2ASMN1; SMN2MEN1 | |
| SCHEMBL757793 | 0.76 | HPGD (0.52) | KAT6AMAPTKMT2ASMN1; SMN2MEN1 | |
| SCHEMBL5899461 | 0.75 | ACLY (0.47) | ACLYKAT6AMAPTKMT2AMEN1 | |
| SCHEMBL5899475 | 0.73 | ALDH1A1 (0.53) | MAPTKMT2ASMN1; SMN2MEN1HPGD | |
| SCHEMBL5899482 | 0.73 | L3MBTL1 (0.60) | KAT6AMAPTKMT2AMEN1ALDH1A1 | |
| SCHEMBL11323836 | 0.72 | HPGD (0.56) | KAT6AMAPTKMT2ASMN1; SMN2MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20060025445-A1 | 11-Beta HSD1 inhibitors | WYETH | 2006-02-02 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060025445-A1 | 11-Beta HSD1 inhibitors | HSD11B1, HSD11B2, HSD3B1 | ACLY 1905/4885KAT6A 2440/4885MAPT 3655/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.