Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 9/20 | 0.59 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.59 |
| ▸ | TSHR | P16473 | 2/20 | 0.58 |
| ▸ | MEP1B | Q16820 | 1/20 | 0.53 |
| ▸ | POLB | P06746 | 2/20 | 0.52 |
| ▸ | LMNA | P02545 | 4/20 | 0.52 |
| ▸ | HTT | P42858 | 3/20 | 0.52 |
| ▸ | CA12 | O43570 | 1/20 | 0.51 |
| ▸ | CA1 | P00915 | 1/20 | 0.51 |
| ▸ | CA2 | P00918 | 1/20 | 0.51 |
| ▸ | CA9 | Q16790 | 1/20 | 0.51 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 1/20 | 0.49 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | NPC1 | O15118 | 1/20 | 0.49 |
| ▸ | GAA | P10253 | 1/20 | 0.49 |
| ▸ | HPGD | P15428 | 1/20 | 0.49 |
| ▸ | RAB9A | P51151 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5899460 | 0.90 | TSHR (0.61) | ALDH1A1SMN1; SMN2TSHRMEP1BLMNA | |
| SCHEMBL9777950 | 0.88 | TSHR (0.59) | ALDH1A1SMN1; SMN2TSHRMEP1BPOLB | |
| SCHEMBL23014131 | 0.83 | ALDH1A1 (0.57) | ALDH1A1TSHRMEP1BCA12CA1 | |
| SCHEMBL10592411 | 0.81 | MMP1 (0.55) | ALDH1A1SMN1; SMN2POLBLMNAHTT | |
| SCHEMBL23014374 | 0.81 | MEP1B (0.54) | ALDH1A1SMN1; SMN2TSHRMEP1BLMNA | |
| SCHEMBL5899469 | 0.81 | ALDH1A1 (0.66) | ALDH1A1SMN1; SMN2TSHRMEP1BPOLB | |
| SCHEMBL15580575 | 0.81 | NPC1 (0.59) | ALDH1A1SMN1; SMN2LMNAKMT2ANPC1 | |
| SCHEMBL10592696 | 0.80 | HTT (0.50) | ALDH1A1SMN1; SMN2LMNAHTTMEN1 | |
| SCHEMBL10463407 | 0.77 | ALDH1A1 (0.79) | ALDH1A1SMN1; SMN2TSHRPOLBLMNA | |
| SCHEMBL11106998 | 0.77 | ALDH1A1 (0.79) | ALDH1A1SMN1; SMN2TSHRPOLBLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20060025445-A1 | 11-Beta HSD1 inhibitors | WYETH | 2006-02-02 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060025445-A1 | 11-Beta HSD1 inhibitors | HSD11B1, HSD11B2, HSD3B1 | ALDH1A1 139/4885SMN1; SMN2 3869/4885TSHR 3445/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.