Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.61 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.58 |
| ▸ | GAA | P10253 | 2/20 | 0.58 |
| ▸ | MEP1B | Q16820 | 1/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.55 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.54 |
| ▸ | CA12 | O43570 | 1/20 | 0.53 |
| ▸ | CA1 | P00915 | 1/20 | 0.53 |
| ▸ | CA2 | P00918 | 1/20 | 0.53 |
| ▸ | CA9 | Q16790 | 1/20 | 0.53 |
| ▸ | PKM | P14618 | 1/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.51 |
| ▸ | NPC1 | O15118 | 1/20 | 0.51 |
| ▸ | HPGD | P15428 | 1/20 | 0.51 |
| ▸ | RAB9A | P51151 | 1/20 | 0.51 |
| ▸ | LMNA | P02545 | 1/20 | 0.51 |
| ▸ | HTT | P42858 | 1/20 | 0.51 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.50 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.50 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5899494 | 0.90 | ALDH1A1 (0.59) | TSHRALDH1A1GAAMEP1BSMN1; SMN2 | |
| SCHEMBL23014131 | 0.85 | ALDH1A1 (0.57) | TSHRALDH1A1MEP1BCA12CA1 | |
| SCHEMBL9777950 | 0.85 | TSHR (0.59) | TSHRALDH1A1MEP1BSMN1; SMN2NPC1 | |
| SCHEMBL5899469 | 0.83 | ALDH1A1 (0.66) | TSHRALDH1A1MEP1BSMN1; SMN2CA12 | |
| SCHEMBL23014374 | 0.83 | MEP1B (0.54) | TSHRALDH1A1GAAMEP1BSMN1; SMN2 | |
| SCHEMBL9778006 | 0.81 | ALDH1A1 (0.67) | ALDH1A1MEP1BCA1CA2PKM | |
| SCHEMBL7637561 | 0.80 | LMNA (0.63) | ALDH1A1SMN1; SMN2CA1CA2NPC1 | |
| SCHEMBL5899545 | 0.79 | CA1 (0.55) | ALDH1A1CA12CA1CA2CA9 | |
| SCHEMBL20981395 | 0.78 | TSHR (0.80) | TSHRALDH1A1GAASMN1; SMN2OPRK1 | |
| SCHEMBL1278961 | 0.78 | TSHR (0.80) | TSHRALDH1A1GAASMN1; SMN2OPRK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20060025445-A1 | 11-Beta HSD1 inhibitors | WYETH | 2006-02-02 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060025445-A1 | 11-Beta HSD1 inhibitors | HSD11B1, HSD11B2, HSD3B1 | TSHR 3445/4885ALDH1A1 139/4885GAA 2422/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.