SCHEMBL5916622

SCHEMBL5916622

CCOC(=O)NCCC[Si](C)(OCC)OCC

nearest known ligand 0.47

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
ACHE P22303 14/20 0.47
HDAC3 O15379 1/20 0.41
HDAC4 P56524 1/20 0.41
HDAC1 Q13547 1/20 0.41
HDAC7 Q8WUI4 1/20 0.41
HDAC2 Q92769 1/20 0.41
HDAC10 Q969S8 1/20 0.41
HDAC11 Q96DB2 1/20 0.41
HDAC8 Q9BY41 1/20 0.41
HDAC6 Q9UBN7 1/20 0.41
HDAC9 Q9UKV0 1/20 0.41
HDAC5 Q9UQL6 1/20 0.41
NCOR2 Q9Y618 1/20 0.41
GLA P06280 1/20 0.40
KMT2A Q03164 1/20 0.40
EPHX1 P07099 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5916808 0.95 ACHE (0.46) ACHEHDAC3HDAC4HDAC1HDAC7
SCHEMBL7572210 0.93 ACHE (0.46) ACHEHDAC3HDAC4HDAC1HDAC7
SCHEMBL5916593 0.93 ACHE (0.46) ACHEHDAC3HDAC4HDAC1HDAC7
SCHEMBL5916503 0.89 KMT2A (0.41) ACHEHDAC3HDAC4HDAC1HDAC7
SCHEMBL5916701 0.87 EPHX1 (0.53) ACHEEPHX1
SCHEMBL13978964 0.87 ACHE (0.69) ACHEEPHX1
SCHEMBL30358659 0.86 ACHE (0.47) ACHEHDAC3HDAC4HDAC1HDAC7
SCHEMBL10018607 0.85 ACHE (0.41) ACHEHDAC3HDAC4HDAC1HDAC7
SCHEMBL8183970 0.84 ALOX15 (0.41) ACHE
SCHEMBL2616704 0.84 ACHE (0.51) ACHE

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 19 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20130079449-A1 Polymer Composition and Method SOLVAY SA (BE) 2013-03-28 US claimed
WO-2013043321-A1 POLYMER COMPOSITION AND METHOD CHEVRON PHILLIPS CHEMICAL COMPANY LP (US) 2013-03-28 WO claimed
EP-3221324-B1 PRODUCTION OF ISOCYANATE FUNCTIONAL ORGANOSILANES WACKER CHEMIE AG (DE) 2019-05-01 EP disclosed
US-10155779-B2 Production of isocyanate functional organosilanes WACKER CHEMIE AG (DE) 2018-12-18 US disclosed
US-9914744-B2 Method for producing carbamatoorganosilanes WACKER CHEMIE AG (DE) 2018-03-13 US disclosed
US-20170320896-A1 PRODUCTION OF ISOCYANATE FUNCTIONAL ORGANOSILANES WACKER CHEMIE AG (DE) 2017-11-09 US disclosed
EP-3221324-A1 PRODUCTION OF ISOCYANATE FUNCTIONAL ORGANOSILANES Wacker Chemie AG (DE) 2017-09-27 EP disclosed
EP-3046925-B1 METHOD FOR PRODUCING CARBAMATOORGANOSILANES WACKER CHEMIE AG (DE) 2017-05-31 EP disclosed
EP-3046925-A1 METHOD FOR PRODUCING CARBAMATOORGANOSILANES Wacker Chemie AG (DE) 2016-07-27 EP disclosed
US-20160200745-A1 METHOD FOR PRODUCING CARBAMATOORGANOSILANES WACKER CHEMIE AG (DE) 2016-07-14 US disclosed
WO-2016078891-A1 PRODUCTION OF ISOCYANATE FUNCTIONAL ORGANOSILANES WACKER CHEMIE AG (DE) 2016-05-26 WO disclosed
WO-2015040070-A1 METHOD FOR PRODUCING CARBAMATOORGANOSILANES WACKER CHEMIE AG (DE) 2015-03-26 WO disclosed
US-20130079449-A1 Polymer Composition and Method SOLVAY SA (BE) 2013-03-28 US disclosed
US-20060247407-A1 Polymers with urea groups and silyl groups and production and use thereof HENKEL KOMMANDITGESELLSCHAFT AUF AKTIEN (HENKEL KGAA) 2006-11-02 US disclosed
US-7057001-B2 Polymers with urea groups and silyl groups and production and use thereof HENKEL KOMMANDITGESELLSCHAFT AUF AKTIEN (HENKEL KGAA) (DE) 2006-06-06 US disclosed
US-20050260401-A1 Polymers with urea groups and silyl groups and production and use thereof HENKEL AG & CO. KGAA (DE) 2005-11-24 US disclosed
EP-1328586-A1 POLYMERS WITH UREA GROUPS AND SILYL GROUPS AND PRODUCTION AND USE THEREOF Henkel Kommanditgesellschaft auf Aktien (DE) 2003-07-23 EP disclosed
WO-2002050020-A1 METHOD FOR PRODUCING ISOCYANATES HENKEL KOMMANDITGESELLSCHAFT AUF AKTIEN (DE) 2002-06-27 WO disclosed
WO-2002034838-A1 POLYMERS WITH UREA GROUPS AND SILYL GROUPS AND PRODUCTION AND USE THEREOF HENKEL KOMMANDITGESELLSCHAFT AUF AKTIEN (DE) 2002-05-02 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20160200745-A1 METHOD FOR PRODUCING CARBAMATOORGANOSILANES RCC2, DDT, NPEPPS ACHE 273/4885HDAC3 3381/4885HDAC4 3878/4885
US-10155779-B2 Production of isocyanate functional organosilanes PKD1, PCK1, PRKCA ACHE 2078/4885HDAC3 1253/4885HDAC4 917/4885
US-20170320896-A1 PRODUCTION OF ISOCYANATE FUNCTIONAL ORGANOSILANES PKD1, PCK1, PRKCA ACHE 2078/4885HDAC3 1253/4885HDAC4 917/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.