Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H4 | Q96RI1 | 17/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | PKM | P14618 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5924630 | 0.77 | KCNH2 (0.35) | NR1H4 | |
| SCHEMBL5924819 | 0.74 | NR1H4 (0.36) | NR1H4ALDH1A1LMNAGAAPKM | |
| SCHEMBL5924626 | 0.65 | IDO1 (0.41) | ALDH1A1GAA | |
| SCHEMBL18241849 | 0.64 | ALDH1A1 (0.48) | ALDH1A1LMNA | |
| SCHEMBL18243444 | 0.64 | CHRM5 (0.52) | ALDH1A1PKM | |
| SCHEMBL8440402 | 0.62 | TSHR (0.42) | — | |
| SCHEMBL18242457 | 0.61 | TP53 (0.39) | ALDH1A1LMNA | |
| SCHEMBL4615977 | 0.61 | NFE2L2 (0.45) | — | |
| SCHEMBL27320995 | 0.60 | HPGD (0.44) | ALDH1A1LMNA | |
| SCHEMBL8438588 | 0.60 | HCAR2 (0.36) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20060122184-A1 | Cyanomethyl derivatives as cysteine protease inhibitors | AXYS PHARMACEUTICALS, INC. (US) | 2006-06-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060122184-A1 | Cyanomethyl derivatives as cysteine protease inhibitors | CTSF, CTSB, CTSK | NR1H4 3746/4885ALDH1A1 3662/4885LMNA 1636/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.