Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.58 |
| ▸ | MAPT | P10636 | 5/20 | 0.56 |
| ▸ | LMNA | P02545 | 3/20 | 0.48 |
| ▸ | CTSB | P07858 | 2/20 | 0.44 |
| ▸ | AR | P10275 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 4/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.41 |
| ▸ | GAA | P10253 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | USP2 | O75604 | 1/20 | 0.40 |
| ▸ | TNNI3 | P19429 | 1/20 | 0.40 |
| ▸ | TNNT2 | P45379 | 1/20 | 0.40 |
| ▸ | TNNC1 | P63316 | 1/20 | 0.40 |
| ▸ | PKM | P14618 | 2/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL519289 | 0.81 | CTSB (0.62) | ALDH1A1MAPTLMNACTSBPOLB | |
| SCHEMBL29847859 | 0.81 | MAPT (0.56) | ALDH1A1KMT2AMAPTLMNACYP1A2 | |
| SCHEMBL16513957 | 0.81 | MAPT (0.56) | ALDH1A1KMT2AMAPTLMNACYP1A2 | |
| SCHEMBL853018 | 0.79 | MAPT (0.60) | ALDH1A1KMT2AMAPTLMNACTSB | |
| SCHEMBL11891609 | 0.79 | MAPT (0.47) | ALDH1A1KMT2AMAPTLMNACTSB | |
| SCHEMBL4247986 | 0.77 | ALDH1A1 (0.58) | ALDH1A1KMT2AMAPTLMNACTSB | |
| SCHEMBL16822909 | 0.76 | MAPT (0.50) | ALDH1A1KMT2AMAPTLMNACTSB | |
| SCHEMBL16513522 | 0.76 | ALDH1A1 (0.53) | ALDH1A1KMT2AMAPTLMNAPOLB | |
| SCHEMBL7715875 | 0.76 | LMNA (0.59) | ALDH1A1KMT2AMAPTLMNACTSB | |
| SCHEMBL5945309 | 0.75 | ALDH1A1 (0.62) | ALDH1A1KMT2AMAPTLMNACYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120190713-A1 | ANTIMICROBIAL ORTHO-FLUOROPHENYL OXAZOLIDINONES FOR TREATMENT OF BACTERIAL INFECTIONS | GORDEEV MIKHAIL FEDOROVICH (US) | 2012-07-26 | — | — | US | disclosed |
| US-20120190713-A1 | ANTIMICROBIAL ORTHO-FLUOROPHENYL OXAZOLIDINONES FOR TREATMENT OF BACTERIAL INFECTIONS | GORDEEV MIKHAIL FEDOROVICH (US) | 2012-07-26 | — | — | US | disclosed |
| US-8178683-B2 | Antimicrobial ortho-fluorophenyl oxazolidinones for treatment of bacterial infections | MICURX PHARMACEUTICALS, INC. (KY) | 2012-05-15 | — | — | US | disclosed |
| US-20100204477-A1 | Methods and Processes For Syntheses and Manufacture of Antimicrobial 1(Ortho-Fluorophenyl)dihydropyridones | MICURX PHARMACEUTICALS, INC. (KY) | 2010-08-12 | — | — | US | disclosed |
| US-20100204477-A1 | Methods and Processes For Syntheses and Manufacture of Antimicrobial 1(Ortho-Fluorophenyl)dihydropyridones | MICURX PHARMACEUTICALS, INC. (KY) | 2010-08-12 | — | — | US | disclosed |
| US-20090048305-A1 | Antimicrobial ortho-Fluorophenyl Oxazolidinones For Treatment of Bacterial Infections | SHANGHAI MICURX PHARMACEUTICAL CO. LTD. (CN) | 2009-02-19 | — | — | US | disclosed |
| US-20090048305-A1 | Antimicrobial ortho-Fluorophenyl Oxazolidinones For Treatment of Bacterial Infections | SHANGHAI MICURX PHARMACEUTICAL CO. LTD. (CN) | 2009-02-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120190713-A1 | ANTIMICROBIAL ORTHO-FLUOROPHENYL OXAZOLIDINONES FOR TREATMENT OF BACTERIAL INFECTIONS | OXA1L, OGFOD1, OLA1 | ALDH1A1 1556/4885KMT2A 4529/4885MAPT 4287/4885 |
| US-20100204477-A1 | Methods and Processes For Syntheses and Manufacture of Antimicrobial 1(Ortho-Fluorophenyl)dihydropyridones | DHPS, FDPS, CYP2F1 | ALDH1A1 232/4885KMT2A 4764/4885MAPT 2269/4885 |
| US-20090048305-A1 | Antimicrobial ortho-Fluorophenyl Oxazolidinones For Treatment of Bacterial Infections | OXA1L, OGFOD1, OLA1 | ALDH1A1 1556/4885KMT2A 4529/4885MAPT 4287/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.