Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC22A12 | Q96S37 | 2/20 | 0.40 |
| ▸ | EYA3 | Q99504 | 2/20 | 0.40 |
| ▸ | LCK | P06239 | 1/20 | 0.38 |
| ▸ | ESR2 | Q92731 | 2/20 | 0.38 |
| ▸ | ESR1 | P03372 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.37 |
| ▸ | MAOA | P21397 | 2/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | PDE2A | O00408 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 4/20 | 0.36 |
| ▸ | RAB9A | P51151 | 3/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | NPC1 | O15118 | 2/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | THRB | P10828 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | CASP3 | P42574 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3264173 | 0.77 | KDM4E (0.46) | MAPTRAB9ALMNAALOX15SMN1; SMN2 | |
| SCHEMBL5308204 | 0.67 | MAPT (0.64) | ESR2ESR1CYP3A4MAOACYP1A2 | |
| SCHEMBL12660566 | 0.66 | KDM4E (0.69) | LCKESR2ESR1CYP3A4MAOA | |
| SCHEMBL12660569 | 0.66 | KDM4E (0.51) | LCKESR2ESR1CYP3A4MAOA | |
| SCHEMBL6483512 | 0.65 | MAPT (0.62) | LCKESR2ESR1CYP3A4MAOA | |
| SCHEMBL9296359 | 0.65 | GABRA1 (0.47) | ESR2ESR1MAPTHPGDKDM4E | |
| SCHEMBL2141567 | 0.64 | EYA3 (0.69) | SLC22A12EYA3ESR1CYP3A4CYP1A2 | |
| SCHEMBL2503422 | 0.64 | GABRA1 (0.46) | ESR2ESR1MAPTHPGDKDM4E | |
| SCHEMBL739294 | 0.61 | HSD17B3 (0.68) | LCKCYP1A2LMNAHPGDKDM4E | |
| SCHEMBL23532095 | 0.61 | SLC22A12 (0.42) | SLC22A12EYA3CYP1A2CYP2C19MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7005448-B2 | Aminoalkyl-benzofuran-5-ol compounds for the treatment of glaucoma | ALCON, INC. (CH) | 2006-02-28 | — | — | US | disclosed |
| US-20040259941-A1 | Aminoalkyl-benzofuran-5-ol compounds for the treatment of glaucoma | NOVARTIS AG (CH) | 2004-12-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040259941-A1 | Aminoalkyl-benzofuran-5-ol compounds for the treatment of glaucoma | TRPC5, TRPV5, PDE5A | SLC22A12 1325/4885EYA3 52/4885LCK 4202/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.