Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FLT3 | P36888 | 2/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | GLA | P06280 | 1/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | CASP1 | P29466 | 1/20 | 0.45 |
| ▸ | BRCA1 | P38398 | 1/20 | 0.45 |
| ▸ | CASP7 | P55210 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.45 |
| ▸ | LCK | P06239 | 1/20 | 0.44 |
| ▸ | CA2 | P00918 | 2/20 | 0.44 |
| ▸ | ESR1 | P03372 | 1/20 | 0.44 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.44 |
| ▸ | APP | P05067 | 3/20 | 0.43 |
| ▸ | CLK1 | P49759 | 2/20 | 0.43 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.43 |
| ▸ | DYRK1B | Q9Y463 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3264177 | 0.78 | LOXL2 (0.59) | FLT3KDM4ESMN1; SMN2HSD17B10CA2 | |
| SCHEMBL17577773 | 0.75 | FLT3 (0.52) | FLT3KDM4EALDH1A1LMNAGLA | |
| SCHEMBL2270984 | 0.74 | KDM4E (0.51) | FLT3KDM4EALDH1A1LMNAGLA | |
| SCHEMBL2270748 | 0.71 | ALOX15 (0.50) | FLT3KDM4EALDH1A1LMNAGLA | |
| SCHEMBL9137025 | 0.71 | ESR1 (0.51) | FLT3KDM4EALDH1A1LMNAGLA | |
| SCHEMBL13021674 | 0.71 | LMNA (0.49) | FLT3KDM4EALDH1A1LMNAGLA | |
| SCHEMBL3903180 | 0.70 | FLT3 (0.54) | FLT3KDM4EALDH1A1LMNAGLA | |
| SCHEMBL2330441 | 0.69 | ALOX15 (0.58) | FLT3KDM4EALDH1A1LMNAGLA | |
| SCHEMBL15157277 | 0.69 | MAOA (0.49) | FLT3KDM4EALDH1A1LMNAGLA | |
| SCHEMBL6867695 | 0.69 | MAOB (0.50) | FLT3KDM4EALDH1A1LMNAGLA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7005448-B2 | Aminoalkyl-benzofuran-5-ol compounds for the treatment of glaucoma | ALCON, INC. (CH) | 2006-02-28 | — | — | US | disclosed |
| US-20040259941-A1 | Aminoalkyl-benzofuran-5-ol compounds for the treatment of glaucoma | NOVARTIS AG (CH) | 2004-12-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040259941-A1 | Aminoalkyl-benzofuran-5-ol compounds for the treatment of glaucoma | TRPC5, TRPV5, PDE5A | FLT3 4807/4885KDM4E 849/4885ALDH1A1 1271/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.