Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 3/20 | 0.59 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.59 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.55 |
| ▸ | LMNA | P02545 | 3/20 | 0.55 |
| ▸ | HTT | P42858 | 3/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.52 |
| ▸ | MAPT | P10636 | 3/20 | 0.50 |
| ▸ | PKM | P14618 | 1/20 | 0.47 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.44 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.44 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.44 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.44 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.44 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.44 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.44 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.44 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.44 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.44 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22802288 | 0.91 | MAPT (0.55) | MEN1KMT2ASMN1; SMN2LMNAHTT | |
| SCHEMBL3566797 | 0.85 | HDAC3 (0.57) | MEN1KMT2AMAPTHDAC3HDAC4 | |
| SCHEMBL18591261 | 0.79 | GPR84 (0.50) | MEN1KMT2AMAPTGPR84HTR1A | |
| SCHEMBL5971960 | 0.77 | HTR6 (0.50) | LMNAKDM4EMAPTHDAC3HDAC4 | |
| SCHEMBL30091335 | 0.77 | LMNA (0.49) | MEN1KMT2ASMN1; SMN2LMNAHTT | |
| SCHEMBL22158064 | 0.77 | FEN1 (0.44) | MAPTHDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL28920451 | 0.76 | MET (0.58) | MEN1KMT2ASMN1; SMN2LMNAHTT | |
| SCHEMBL30091143 | 0.76 | MET (0.58) | MEN1KMT2ASMN1; SMN2LMNAHTT | |
| SCHEMBL18555016 | 0.75 | GPR84 (0.50) | MEN1KMT2AMAPTGPR84HTR1A | |
| SCHEMBL947424 | 0.75 | GUSB (0.43) | MEN1KMT2ASMN1; SMN2LMNAHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1309384-C | 4-piperazinyl benzenesulfonyl indoles with 5-HT6 receptor affinity | HOFFMANN LA ROCHE (CH) | 2007-04-11 | — | — | CN | disclosed |
| EP-1556037-B1 | 4-PIPERAZINYL BENZENESULFONYL INDOLES WITH 5-HT6 RECEPTOR AFFINITY | HOFFMANN LA ROCHE (CH) | 2006-11-02 | — | — | EP | disclosed |
| US-7022708-B2 | 4-piperazinyl benzenesulfonyl indoles and uses thereof | ROCHE PALO ALTO LLC (US) | 2006-04-04 | — | — | US | disclosed |
| CN-1705480-A | 4-piperazinyl benzenesulfonyl indoles with 5-HT6 receptor affinity | HOFFMANN LA ROCHE (CH) | 2005-12-07 | — | — | CN | disclosed |
| EP-1556037-A1 | 4-PIPERAZINYL BENZENESULFONYL INDOLES WITH 5-HT6 RECEPTOR AFFINITY | F. HOFFMANN-LA ROCHE AG (CH) | 2005-07-27 | — | — | EP | disclosed |
| US-20040087593-A1 | 4-Piperazinyl benzenesulfonyl indoles and uses thereof | ROCHE PALO ALTO LLC | 2004-05-06 | — | — | US | disclosed |
| WO-2004035047-A1 | 4-PIPERAZINYL BENZENESULFONYL INDOLES WITH 5-HT6 RECEPTOR AFFINITY | F. HOFFMANN-LA ROCHE AG (CH) | 2004-04-29 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040087593-A1 | 4-Piperazinyl benzenesulfonyl indoles and uses thereof | HTR6, HTR4, HTR5A | MEN1 4043/4885KMT2A 2696/4885SMN1; SMN2 4456/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.