Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PKM | P14618 | 2/20 | 0.35 |
| ▸ | PKLR | P30613 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.33 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.33 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.33 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.33 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.33 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.33 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
| ▸ | GRM5 | P41594 | 1/20 | 0.32 |
| ▸ | HTR6 | P50406 | 2/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
| ▸ | SLC6A9 | P48067 | 1/20 | 0.32 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.32 |
| ▸ | FEN1 | P39748 | 1/20 | 0.32 |
| ▸ | FABP1 | P07148 | 2/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5983331 | 1.00 | PKM (0.35) | PKMPKLRALDH1A1MAPTL3MBTL1 | |
| SCHEMBL4623170 | 0.79 | PSEN1 (0.36) | PKMALDH1A1MAPTL3MBTL1PTGDR2 | |
| SCHEMBL5982509 | 0.78 | ALDH1A1 (0.40) | PKMALDH1A1MAPTL3MBTL1 | |
| SCHEMBL5982520 | 0.78 | ALDH1A1 (0.40) | PKMALDH1A1MAPTL3MBTL1 | |
| SCHEMBL4622098 | 0.70 | ELOVL6 (0.39) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL4623174 | 0.70 | PSEN1 (0.36) | PKMPKLRALDH1A1MAPTL3MBTL1 | |
| SCHEMBL14040429 | 0.70 | ALDH1A1 (0.31) | ALDH1A1CYP1A2MEN1KMT2A | |
| SCHEMBL11040609 | 0.69 | ALDH1A1 (0.38) | PKMALDH1A1MAPTL3MBTL1CYP1A2 | |
| SCHEMBL11040612 | 0.69 | ALDH1A1 (0.38) | PKMALDH1A1MAPTL3MBTL1CYP1A2 | |
| SCHEMBL13784248 | 0.69 | PKM (0.40) | PKMPKLRALDH1A1L3MBTL1PSEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20060052365-A1 | Protease inhibitors | SMITHKLINE BEECHAM CORPORATION | 2006-03-09 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060052365-A1 | Protease inhibitors | CTSS, CTSE, CMA1 | PKM 3396/4885PKLR 2061/4885ALDH1A1 1528/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.