Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MET | P08581 | 3/20 | 0.44 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.44 |
| ▸ | MAOA | P21397 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | BTK | Q06187 | 2/20 | 0.43 |
| ▸ | TEC | P42680 | 1/20 | 0.43 |
| ▸ | TXK | P42681 | 1/20 | 0.43 |
| ▸ | BLK | P51451 | 1/20 | 0.43 |
| ▸ | BMX | P51813 | 1/20 | 0.43 |
| ▸ | ERBB4 | Q15303 | 1/20 | 0.43 |
| ▸ | AXL | P30530 | 1/20 | 0.42 |
| ▸ | ACHE | P22303 | 1/20 | 0.42 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.42 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.42 |
| ▸ | TGFBR2 | P37173 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | EGFR | P00533 | 1/20 | 0.41 |
| ▸ | LTA4H | P09960 | 1/20 | 0.41 |
| ▸ | RUNX1 | Q01196 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6005314 | 0.82 | HRH3 (0.49) | — | |
| SCHEMBL6004922 | 0.82 | SLC22A12 (0.39) | METMAOABTKAXLTGFBR1 | |
| SCHEMBL6004262 | 0.82 | ALDH1A1 (0.36) | METAXLTGFBR1KDM4EALDH1A1 | |
| SCHEMBL6004162 | 0.82 | ALDH1A1 (0.36) | METFGFR2AXLTGFBR1ALDH1A1 | |
| SCHEMBL6005251 | 0.81 | PDE2A (0.39) | METBTKAXLTGFBR1EGFR | |
| SCHEMBL6004825 | 0.81 | SLC6A2 (0.52) | MAOAACHE | |
| SCHEMBL6005366 | 0.78 | PDGFRB (0.36) | METFGFR2AXLTGFBR1 | |
| SCHEMBL6004251 | 0.78 | TGFBR1 (0.39) | BTKAXLACHETGFBR1EGFR | |
| SCHEMBL6004285 | 0.78 | CYP3A4 (0.46) | MAOANPC1MEN1KMT2AKDM4E | |
| SCHEMBL6004932 | 0.77 | IRAK4 (0.39) | MAOA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1724268-A1 | COMPOUND HAVING TGF-BETA INHIBITORY ACTIVITY AND PHARMACEUTICAL COMPOSITION CONTAINING SAME | KIRIN BEER KABUSHIKI KAISHA (JP) | 2006-11-22 | — | — | EP | disclosed |