Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | CASP1 | P29466 | 1/20 | 0.36 |
| ▸ | CASP7 | P55210 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.36 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.36 |
| ▸ | AXL | P30530 | 1/20 | 0.35 |
| ▸ | DDR2 | Q16832 | 1/20 | 0.34 |
| ▸ | SYK | P43405 | 2/20 | 0.33 |
| ▸ | AURKA | O14965 | 2/20 | 0.33 |
| ▸ | LCK | P06239 | 2/20 | 0.33 |
| ▸ | KDR | P35968 | 2/20 | 0.33 |
| ▸ | TEK | Q02763 | 2/20 | 0.33 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.33 |
| ▸ | INCENP | Q9NQS7 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6004162 | 0.96 | ALDH1A1 (0.36) | ALDH1A1CASP1CASP7HSD17B10PDGFRB | |
| SCHEMBL6005251 | 0.91 | PDE2A (0.39) | ALDH1A1CASP1CASP7HSD17B10PDGFRB | |
| SCHEMBL6004922 | 0.90 | SLC22A12 (0.39) | ALDH1A1CASP1CASP7HSD17B10PDGFRB | |
| SCHEMBL6005366 | 0.85 | PDGFRB (0.36) | PDGFRBPDGFRAAXLDDR2SYK | |
| SCHEMBL6004251 | 0.85 | TGFBR1 (0.39) | ALDH1A1CASP1CASP7HSD17B10PDGFRB | |
| SCHEMBL6004343 | 0.85 | SIGMAR1 (0.36) | ALDH1A1CASP1CASP7HSD17B10PDGFRB | |
| SCHEMBL6004285 | 0.84 | CYP3A4 (0.46) | ALDH1A1HSD17B10SYKAURKBINCENP | |
| SCHEMBL6004333 | 0.84 | PDGFRA (0.42) | PDGFRBPDGFRAAXLTGFBR1 | |
| SCHEMBL6005281 | 0.83 | DDR2 (0.34) | PDGFRBPDGFRAAXLDDR2AURKA | |
| SCHEMBL6002950 | 0.82 | MET (0.44) | ALDH1A1AXLKDM4EMETTGFBR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1724268-A1 | COMPOUND HAVING TGF-BETA INHIBITORY ACTIVITY AND PHARMACEUTICAL COMPOSITION CONTAINING SAME | KIRIN BEER KABUSHIKI KAISHA (JP) | 2006-11-22 | — | — | EP | disclosed |