Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE2A | O00408 | 5/20 | 0.39 |
| ▸ | PDE10A | Q9Y233 | 4/20 | 0.39 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | CASP1 | P29466 | 1/20 | 0.36 |
| ▸ | CASP7 | P55210 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | DDR2 | Q16832 | 1/20 | 0.35 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.35 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.35 |
| ▸ | AXL | P30530 | 1/20 | 0.35 |
| ▸ | AURKA | O14965 | 2/20 | 0.35 |
| ▸ | LCK | P06239 | 2/20 | 0.35 |
| ▸ | KDR | P35968 | 2/20 | 0.35 |
| ▸ | TEK | Q02763 | 2/20 | 0.35 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.34 |
| ▸ | SRC | P12931 | 2/20 | 0.34 |
| ▸ | TGFBR1 | P36897 | 2/20 | 0.34 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.34 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6004922 | 0.95 | SLC22A12 (0.39) | PDE2APDE10ATLR8ALDH1A1CASP1 | |
| SCHEMBL6004262 | 0.91 | ALDH1A1 (0.36) | ALDH1A1CASP1CASP7HSD17B10DDR2 | |
| SCHEMBL6004343 | 0.90 | SIGMAR1 (0.36) | PDE2APDE10AALDH1A1CASP1CASP7 | |
| SCHEMBL6004162 | 0.89 | ALDH1A1 (0.36) | ALDH1A1CASP1CASP7HSD17B10DDR2 | |
| SCHEMBL6004782 | 0.87 | MCL1 (0.33) | ALDH1A1CASP1CASP7HSD17B10PDGFRA | |
| SCHEMBL6005281 | 0.86 | DDR2 (0.34) | DDR2PDGFRBPDGFRAAXLAURKA | |
| SCHEMBL6005366 | 0.84 | PDGFRB (0.36) | DDR2PDGFRBPDGFRAAXLKDR | |
| SCHEMBL6004251 | 0.84 | TGFBR1 (0.39) | ALDH1A1CASP1CASP7HSD17B10PDGFRB | |
| SCHEMBL6005265 | 0.84 | TGFBR1 (0.44) | PDE2APDE10AALDH1A1CASP1CASP7 | |
| SCHEMBL6004285 | 0.84 | CYP3A4 (0.46) | ALDH1A1HSD17B10AURKB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1724268-A1 | COMPOUND HAVING TGF-BETA INHIBITORY ACTIVITY AND PHARMACEUTICAL COMPOSITION CONTAINING SAME | KIRIN BEER KABUSHIKI KAISHA (JP) | 2006-11-22 | — | — | EP | disclosed |