Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ERN1 | O75460 | 4/20 | 0.40 |
| ▸ | CDC7 | O00311 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.34 |
| ▸ | GLA | P06280 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | ESR1 | P03372 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.34 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.34 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.34 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | PGK1 | P00558 | 1/20 | 0.34 |
| ▸ | PTGER2 | P43116 | 1/20 | 0.33 |
| ▸ | CNR2 | P34972 | 1/20 | 0.33 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6004130 | 0.78 | PGK1 (0.35) | ERN1CDC7PGK1HTR1ATGFBR1 | |
| SCHEMBL6005298 | 0.73 | SRC (0.44) | PGK1TGFBR1 | |
| SCHEMBL1692394 | 0.72 | DHODH (0.44) | ALDH1A1KDM4EMEN1LMNAKMT2A | |
| SCHEMBL3896975 | 0.71 | KDM4E (0.45) | ALDH1A1KDM4EHSD17B10LMNAPOLB | |
| SCHEMBL6004768 | 0.71 | KDM4E (0.51) | ALDH1A1KDM4EMEN1LMNAKMT2A | |
| SCHEMBL12606346 | 0.68 | RIPK1 (0.56) | — | |
| SCHEMBL27527225 | 0.66 | MMP2 (0.45) | ALDH1A1KDM4EMEN1LMNAMAPT | |
| SCHEMBL6004302 | 0.66 | KDM4E (0.43) | ALDH1A1KDM4EGLAMEN1LMNA | |
| SCHEMBL6004845 | 0.66 | MAPK14 (0.52) | ALDH1A1KDM4EMEN1KMT2A | |
| SCHEMBL6004749 | 0.66 | CYP1A2 (0.41) | ALDH1A1KDM4EMEN1POLBKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1724268-A1 | COMPOUND HAVING TGF-BETA INHIBITORY ACTIVITY AND PHARMACEUTICAL COMPOSITION CONTAINING SAME | KIRIN BEER KABUSHIKI KAISHA (JP) | 2006-11-22 | — | — | EP | disclosed |